Detailed information of TA system TA021942

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 2222976..2223538
• Replicon: chromosome
• Accession: NC_008800
• Organism: Yersinia enterocolitica subsp. enterocolitica 8081

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A1JMS6
• Locus tag: YE_RS10205
• Protein ID: WP_011816307.1
• Coordinates: 2222976..2223332 (-)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: YE_RS10210
• Protein ID: WP_042661421.1
• Coordinates: 2223329..2223538 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YE_RS10170 (YE2025A)	2218087..2218332	-	246	WP_005165762.1	DUF1161 domain-containing protein	-
YE_RS10175 (YE2026)	2218424..2218795	-	372	WP_005169788.1	DUF1283 family protein	-
YE_RS10180 (YE2026A)	2218992..2219207	+	216	WP_042661419.1	hypothetical protein	-
YE_RS10185 (YE2027)	2219164..2219490	+	327	WP_011816304.1	YnfA family protein	-
YE_RS10190 (YE2028)	2219521..2220270	-	750	WP_005165755.1	bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG	-
YE_RS10195 (YE2029)	2220356..2221786	-	1431	WP_042661420.1	MFS transporter	-
YE_RS10200 (YE2030)	2222032..2222310	-	279	WP_005169775.1	DUF1471 domain-containing protein	-
YE_RS10205 (YE2032)	2222976..2223332	-	357	WP_011816307.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
YE_RS10210 (YE2033)	2223329..2223538	-	210	WP_042661421.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
YE_RS10215 (YE2034)	2224042..2224752	+	711	WP_011816309.1	PAS and helix-turn-helix domain-containing protein	-
YE_RS10220 (YE2035)	2224870..2226117	-	1248	WP_011816310.1	MFS transporter	-
YE_RS10225 (YE2036)	2226606..2227778	+	1173	WP_011816311.1	DNA repair ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (36-79)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-50)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13017.70 Da
• Isoelectric Point: 4.3009

>T21942 WP_011816307.1 NC_008800:c2223332-2222976 [Yersinia enterocolitica subsp. enterocolitica 8081]
MIFLTANDIAEFNAEIIPNGRPDNSKIEAVASRVLNAHHYDNVDDVYQLAAIYLIAISRGHIFLDGNKRTAFQSMALFLG
INGVDLCASNQLEELTVEAAQGKIGVEQITEQLRELTE

Nucleotide

• Length: 357 bp

>T21942 NC_008800:c2223332-2222976 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGATATTTTTAACGGCAAATGATATTGCGGAGTTTAACGCAGAAATTATCCCTAACGGCAGGCCTGATAATAGTAAGAT
TGAGGCTGTAGCCAGCCGCGTATTAAATGCACATCATTATGACAACGTGGATGATGTATATCAGTTAGCCGCTATCTACT
TAATTGCCATTAGTCGAGGTCACATTTTTCTTGATGGGAACAAGCGCACGGCATTTCAAAGCATGGCGCTGTTCCTTGGT
ATAAATGGCGTAGACCTGTGTGCAAGCAATCAACTGGAAGAATTAACCGTTGAAGCAGCGCAAGGAAAAATTGGTGTTGA
GCAGATAACGGAACAGTTACGCGAGCTTACCGAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7845.08 Da
• Isoelectric Point: 10.1356

>AT21942 WP_042661421.1 NC_008800:c2223538-2223329 [Yersinia enterocolitica subsp. enterocolitica 8081]
MNSISYTAARNNLAKVLLEAQKQPVEITRRGQSEVYIISKADYEDLMKAKVKAHIQFKHAETIKALADR

Nucleotide

• Length: 210 bp

>AT21942 NC_008800:c2223538-2223329 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGAATAGCATCAGTTATACAGCCGCAAGAAATAATTTAGCCAAGGTATTATTGGAAGCACAAAAGCAGCCCGTAGAAAT
CACGCGCCGTGGGCAGAGTGAGGTCTATATTATCAGCAAGGCTGATTATGAGGATTTGATGAAAGCAAAGGTAAAGGCAC
ATATTCAATTTAAACATGCAGAAACCATTAAAGCTCTTGCTGATAGATGA

Structures

Toxin

• AlphaFold DB: A1JMS6