Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 95291..95817 | Replicon | plasmid pKqq_SB98_1 |
| Accession | NZ_CP084804 | ||
| Organism | Klebsiella quasipneumoniae subsp. quasipneumoniae strain SB98 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | LGM23_RS26615 | Protein ID | WP_000323025.1 |
| Coordinates | 95291..95578 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | J5W3H0 |
| Locus tag | LGM23_RS26620 | Protein ID | WP_004196370.1 |
| Coordinates | 95578..95817 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGM23_RS26585 (LGM23_26585) | 90646..90993 | - | 348 | WP_032719514.1 | hypothetical protein | - |
| LGM23_RS26590 (LGM23_26590) | 91149..92216 | - | 1068 | WP_060617697.1 | hypothetical protein | - |
| LGM23_RS26595 (LGM23_26595) | 92906..93283 | + | 378 | WP_004181901.1 | hypothetical protein | - |
| LGM23_RS26600 (LGM23_26600) | 93481..94455 | - | 975 | WP_181400647.1 | Hok/Gef family protein | - |
| LGM23_RS28805 | 95061..95219 | - | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| LGM23_RS26615 (LGM23_26615) | 95291..95578 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| LGM23_RS26620 (LGM23_26620) | 95578..95817 | - | 240 | WP_004196370.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| LGM23_RS26625 (LGM23_26625) | 95842..95940 | + | 99 | Protein_95 | hypothetical protein | - |
| LGM23_RS26630 (LGM23_26630) | 96068..96433 | + | 366 | WP_009651956.1 | hypothetical protein | - |
| LGM23_RS26635 (LGM23_26635) | 96477..97214 | + | 738 | WP_008460272.1 | HupE/UreJ family protein | - |
| LGM23_RS26640 (LGM23_26640) | 97228..97917 | + | 690 | WP_004196322.1 | hypothetical protein | - |
| LGM23_RS26645 (LGM23_26645) | 97948..99324 | - | 1377 | WP_004196363.1 | chromate efflux transporter | - |
| LGM23_RS26650 (LGM23_26650) | 99281..100258 | - | 978 | WP_004196334.1 | chromate resistance protein | - |
| LGM23_RS26655 (LGM23_26655) | 100288..100480 | + | 193 | Protein_101 | MFS transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | pla | 1..332984 | 332984 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T219418 WP_000323025.1 NZ_CP084804:c95578-95291 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T219418 NZ_CP116409:1344572-1344907 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 80 a.a. Molecular weight: 9018.43 Da Isoelectric Point: 4.3894
>AT219418 WP_004196370.1 NZ_CP084804:c95817-95578 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL
Download Length: 240 bp
>AT219418 NZ_CP116409:1344324-1344572 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|