Detailed information of TA system TA219417

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4877493..4878009
• Replicon: chromosome
• Accession: NZ_CP084803
• Organism: Klebsiella quasipneumoniae subsp. quasipneumoniae strain SB98

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LGM23_RS23635
• Protein ID: WP_080820655.1
• Coordinates: 4877493..4877777 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1C1EW86
• Locus tag: LGM23_RS23640
• Protein ID: WP_023291757.1
• Coordinates: 4877767..4878009 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGM23_RS23625 (4874491)	4874491..4876629	+	2139	WP_080820653.1	anaerobic ribonucleoside-triphosphate reductase	-
LGM23_RS23630 (4877025)	4877025..4877489	+	465	WP_012969085.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LGM23_RS23635 (4877493)	4877493..4877777	-	285	WP_080820655.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LGM23_RS23640 (4877767)	4877767..4878009	-	243	WP_023291757.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LGM23_RS23645 (4878087)	4878087..4879997	-	1911	WP_044525201.1	PRD domain-containing protein	-
LGM23_RS23650 (4880020)	4880020..4881171	-	1152	WP_023291755.1	lactonase family protein	-
LGM23_RS23655 (4881238)	4881238..4881978	-	741	WP_017900574.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10957.79 Da
• Isoelectric Point: 10.3796

>T219417 WP_080820655.1 NZ_CP084803:c4877777-4877493 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MTYELAFDPRAWREWQKLGETIKKQFKNKLQQVVENPRIASASLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T219417 NZ_CP116409:1190532-1190939 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9119.58 Da
• Isoelectric Point: 4.8146

>AT219417 WP_023291757.1 NZ_CP084803:c4878009-4877767 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDSEAALLRTVRERLENPQPEVKVSLDDL

Nucleotide

• Length: 243 bp

>AT219417 NZ_CP116409:1190285-1190551 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1C1EW86