Detailed information of TA system TA219416

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 4336890..4337582
• Replicon: chromosome
• Accession: NZ_CP084803
• Organism: Klebsiella quasipneumoniae subsp. quasipneumoniae strain SB98

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: LGM23_RS21160
• Protein ID: WP_064155227.1
• Coordinates: 4337244..4337582 (+)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: LGM23_RS21155
• Protein ID: WP_074186702.1
• Coordinates: 4336890..4337219 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGM23_RS21140 (4331924)	4331924..4335940	-	4017	WP_124070472.1	hypothetical protein	-
LGM23_RS21150 (4336387)	4336387..4336866	+	480	WP_064155225.1	DNA repair protein RadC	-
LGM23_RS21155 (4336890)	4336890..4337219	+	330	WP_074186702.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
LGM23_RS21160 (4337244)	4337244..4337582	+	339	WP_064155227.1	TA system toxin CbtA family protein	Toxin
LGM23_RS21165 (4337974)	4337974..4338723	+	750	WP_048291272.1	hypothetical protein	-
LGM23_RS21170 (4339329)	4339329..4341974	-	2646	WP_167878740.1	LuxR C-terminal-related transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-107)

Antitoxin

• Antitoxin CbeA (9-108)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12911.82 Da
• Isoelectric Point: 8.5252

>T219416 WP_064155227.1 NZ_CP084803:4337244-4337582 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MKTLPANQRVAKPCPPPVLVWQTLLTRLLEQHYGLTLNDTPFSDENVIQEHINDGITLADAINFLVEKYELVRIDRRGFN
CQEQSPYLRAVDILRARQATGLLRQRHHPSAR

Nucleotide

• Length: 339 bp

>T219416 NZ_CP116409:c1072664-1072287 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACAATGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12373.85 Da
• Isoelectric Point: 5.8867

>AT219416 WP_074186702.1 NZ_CP084803:4336890-4337219 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MDKETDTVRWGLNRPGSPQLGARLVQEGNRLHYLADRAGTTGAFNEEECHQLNSAFPHFIEQMELMLLSGELNPRHAHRV
TLYHNELTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 330 bp

>AT219416 NZ_CP116409:c1073088-1072711 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA