Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4163442..4164061 Replicon chromosome
Accession NZ_CP084803
Organism Klebsiella quasipneumoniae subsp. quasipneumoniae strain SB98

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LGM23_RS20275 Protein ID WP_002892050.1
Coordinates 4163843..4164061 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LGM23_RS20270 Protein ID WP_002892066.1
Coordinates 4163442..4163816 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM23_RS20260 (4158599) 4158599..4159792 + 1194 WP_023288645.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LGM23_RS20265 (4159815) 4159815..4162961 + 3147 WP_023288644.1 multidrug efflux RND transporter permease subunit AcrB -
LGM23_RS20270 (4163442) 4163442..4163816 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LGM23_RS20275 (4163843) 4163843..4164061 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LGM23_RS20280 (4164220) 4164220..4164786 + 567 WP_023288643.1 maltose O-acetyltransferase -
LGM23_RS20285 (4164758) 4164758..4164889 - 132 WP_162543094.1 hypothetical protein -
LGM23_RS20290 (4164923) 4164923..4165393 + 471 WP_064155186.1 YlaC family protein -
LGM23_RS20295 (4165362) 4165362..4166819 - 1458 WP_064155187.1 PLP-dependent aminotransferase family protein -
LGM23_RS20300 (4166920) 4166920..4167618 + 699 WP_044521289.1 GNAT family protein -
LGM23_RS20305 (4167615) 4167615..4167755 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LGM23_RS20310 (4167755) 4167755..4168018 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T219415 WP_002892050.1 NZ_CP084803:4163843-4164061 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T219415 NZ_CP116409:486474-486581 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT219415 WP_002892066.1 NZ_CP084803:4163442-4163816 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT219415 NZ_CP116409:c486425-486362 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References