Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 4163442..4164061 | Replicon | chromosome |
Accession | NZ_CP084803 | ||
Organism | Klebsiella quasipneumoniae subsp. quasipneumoniae strain SB98 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | LGM23_RS20275 | Protein ID | WP_002892050.1 |
Coordinates | 4163843..4164061 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | LGM23_RS20270 | Protein ID | WP_002892066.1 |
Coordinates | 4163442..4163816 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LGM23_RS20260 (4158599) | 4158599..4159792 | + | 1194 | WP_023288645.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
LGM23_RS20265 (4159815) | 4159815..4162961 | + | 3147 | WP_023288644.1 | multidrug efflux RND transporter permease subunit AcrB | - |
LGM23_RS20270 (4163442) | 4163442..4163816 | + | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
LGM23_RS20275 (4163843) | 4163843..4164061 | + | 219 | WP_002892050.1 | HHA domain-containing protein | Toxin |
LGM23_RS20280 (4164220) | 4164220..4164786 | + | 567 | WP_023288643.1 | maltose O-acetyltransferase | - |
LGM23_RS20285 (4164758) | 4164758..4164889 | - | 132 | WP_162543094.1 | hypothetical protein | - |
LGM23_RS20290 (4164923) | 4164923..4165393 | + | 471 | WP_064155186.1 | YlaC family protein | - |
LGM23_RS20295 (4165362) | 4165362..4166819 | - | 1458 | WP_064155187.1 | PLP-dependent aminotransferase family protein | - |
LGM23_RS20300 (4166920) | 4166920..4167618 | + | 699 | WP_044521289.1 | GNAT family protein | - |
LGM23_RS20305 (4167615) | 4167615..4167755 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
LGM23_RS20310 (4167755) | 4167755..4168018 | - | 264 | WP_004204754.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T219415 WP_002892050.1 NZ_CP084803:4163843-4164061 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T219415 NZ_CP116409:486474-486581 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT219415 WP_002892066.1 NZ_CP084803:4163442-4163816 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT219415 NZ_CP116409:c486425-486362 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |