Detailed information of TA system TA219414

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2695444..2697032
• Replicon: chromosome
• Accession: NZ_CP084803
• Organism: Klebsiella quasipneumoniae subsp. quasipneumoniae strain SB98

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LGM23_RS13270
• Protein ID: WP_064154631.1
• Coordinates: 2695444..2696766 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A2N4W0X3
• Locus tag: LGM23_RS13275
• Protein ID: WP_023289667.1
• Coordinates: 2696766..2697032 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGM23_RS13255 (2690476)	2690476..2693001	+	2526	WP_080819630.1	fimbria/pilus outer membrane usher protein	-
LGM23_RS13260 (2692989)	2692989..2693993	+	1005	WP_064154630.1	fimbrial protein	-
LGM23_RS13265 (2694135)	2694135..2695427	+	1293	WP_044523014.1	glycoside hydrolase family 10 protein	-
LGM23_RS13270 (2695444)	2695444..2696766	-	1323	WP_064154631.1	type II toxin-antitoxin system HipA family toxin	Toxin
LGM23_RS13275 (2696766)	2696766..2697032	-	267	WP_023289667.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LGM23_RS13280 (2697297)	2697297..2697623	-	327	WP_064154632.1	hydroxyisourate hydrolase	-
LGM23_RS13285 (2697620)	2697620..2698120	-	501	WP_032452825.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LGM23_RS13290 (2698098)	2698098..2699477	-	1380	WP_032452824.1	nucleobase:cation symporter-2 family protein	-
LGM23_RS13295 (2699823)	2699823..2700977	+	1155	WP_064154633.1	FAD-dependent urate hydroxylase HpxO	-
LGM23_RS13300 (2700958)	2700958..2701881	-	924	WP_044522995.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49211.54 Da
• Isoelectric Point: 8.6110

>T219414 WP_064154631.1 NZ_CP084803:c2696766-2695444 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDDEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATRGRKTEINAIYPRHFLATAKAVNFPRDQMLAILDEFADRVP
QAIESARRTLPVDFSAHVWRAITENMLKLHARLQQGLQAR

Nucleotide

• Length: 1323 bp

>T219414 NZ_CP116409:485991-486098 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9891.25 Da
• Isoelectric Point: 7.3163

>AT219414 WP_023289667.1 NZ_CP084803:c2697032-2696766 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MHSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETATAP
DNTTDLDW

Nucleotide

• Length: 267 bp

>AT219414 NZ_CP116409:c485942-485879 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Antitoxin

• AlphaFold DB: A0A2N4W0X3