Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 797121..797778 Replicon chromosome
Accession NZ_CP084803
Organism Klebsiella quasipneumoniae subsp. quasipneumoniae strain SB98

Toxin (Protein)


Gene name cptA Uniprot ID A0A2N4VX63
Locus tag LGM23_RS03945 Protein ID WP_023290968.1
Coordinates 797368..797778 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM23_RS03940 Protein ID WP_002916312.1
Coordinates 797121..797387 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM23_RS03915 (792271) 792271..793704 - 1434 WP_064158015.1 6-phospho-beta-glucosidase -
LGM23_RS03920 (793823) 793823..794551 - 729 WP_032454033.1 MurR/RpiR family transcriptional regulator -
LGM23_RS03925 (794602) 794602..794913 + 312 WP_064158016.1 N(4)-acetylcytidine aminohydrolase -
LGM23_RS03930 (795077) 795077..795736 + 660 WP_008806429.1 hemolysin III family protein -
LGM23_RS03935 (795892) 795892..796875 - 984 WP_064158017.1 tRNA-modifying protein YgfZ -
LGM23_RS03940 (797121) 797121..797387 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM23_RS03945 (797368) 797368..797778 + 411 WP_023290968.1 protein YgfX Toxin
LGM23_RS03950 (797785) 797785..798306 - 522 WP_004205324.1 flavodoxin FldB -
LGM23_RS03955 (798407) 798407..799303 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM23_RS03960 (799326) 799326..800039 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM23_RS03965 (800045) 800045..801778 + 1734 WP_032454029.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.89 Da        Isoelectric Point: 11.4778

>T219405 WP_023290968.1 NZ_CP084803:797368-797778 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219405 NZ_CP116405:2714234-2714341 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219405 WP_002916312.1 NZ_CP084803:797121-797387 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219405 NZ_CP116405:c2714184-2714121 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N4VX63

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References