Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 797121..797778 | Replicon | chromosome |
Accession | NZ_CP084803 | ||
Organism | Klebsiella quasipneumoniae subsp. quasipneumoniae strain SB98 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | A0A2N4VX63 |
Locus tag | LGM23_RS03945 | Protein ID | WP_023290968.1 |
Coordinates | 797368..797778 (+) | Length | 137 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | W8UQ37 |
Locus tag | LGM23_RS03940 | Protein ID | WP_002916312.1 |
Coordinates | 797121..797387 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LGM23_RS03915 (792271) | 792271..793704 | - | 1434 | WP_064158015.1 | 6-phospho-beta-glucosidase | - |
LGM23_RS03920 (793823) | 793823..794551 | - | 729 | WP_032454033.1 | MurR/RpiR family transcriptional regulator | - |
LGM23_RS03925 (794602) | 794602..794913 | + | 312 | WP_064158016.1 | N(4)-acetylcytidine aminohydrolase | - |
LGM23_RS03930 (795077) | 795077..795736 | + | 660 | WP_008806429.1 | hemolysin III family protein | - |
LGM23_RS03935 (795892) | 795892..796875 | - | 984 | WP_064158017.1 | tRNA-modifying protein YgfZ | - |
LGM23_RS03940 (797121) | 797121..797387 | + | 267 | WP_002916312.1 | FAD assembly factor SdhE | Antitoxin |
LGM23_RS03945 (797368) | 797368..797778 | + | 411 | WP_023290968.1 | protein YgfX | Toxin |
LGM23_RS03950 (797785) | 797785..798306 | - | 522 | WP_004205324.1 | flavodoxin FldB | - |
LGM23_RS03955 (798407) | 798407..799303 | + | 897 | WP_004144729.1 | site-specific tyrosine recombinase XerD | - |
LGM23_RS03960 (799326) | 799326..800039 | + | 714 | WP_002916301.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
LGM23_RS03965 (800045) | 800045..801778 | + | 1734 | WP_032454029.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 16075.89 Da Isoelectric Point: 11.4778
>T219405 WP_023290968.1 NZ_CP084803:797368-797778 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE
Download Length: 411 bp
>T219405 NZ_CP116405:2714234-2714341 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10480.98 Da Isoelectric Point: 5.1116
>AT219405 WP_002916312.1 NZ_CP084803:797121-797387 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI
Download Length: 267 bp
>AT219405 NZ_CP116405:c2714184-2714121 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2N4VX63 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GY41 |