Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4304812..4305469 Replicon chromosome
Accession NZ_CP084783
Organism Klebsiella quasipneumoniae subsp. similipneumoniae strain 09A323

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag LGM26_RS20760 Protein ID WP_004205323.1
Coordinates 4304812..4305222 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM26_RS20765 Protein ID WP_002916312.1
Coordinates 4305203..4305469 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM26_RS20740 (4300812) 4300812..4302545 - 1734 WP_017899799.1 single-stranded-DNA-specific exonuclease RecJ -
LGM26_RS20745 (4302551) 4302551..4303264 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM26_RS20750 (4303287) 4303287..4304183 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM26_RS20755 (4304284) 4304284..4304805 + 522 WP_004205324.1 flavodoxin FldB -
LGM26_RS20760 (4304812) 4304812..4305222 - 411 WP_004205323.1 protein YgfX Toxin
LGM26_RS20765 (4305203) 4305203..4305469 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM26_RS20770 (4305715) 4305715..4306698 + 984 WP_017899798.1 tRNA-modifying protein YgfZ -
LGM26_RS20775 (4306797) 4306797..4307456 - 660 WP_004205319.1 hemolysin III family protein -
LGM26_RS20780 (4307619) 4307619..4307930 - 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
LGM26_RS20785 (4307980) 4307980..4308708 + 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
LGM26_RS20790 (4308827) 4308827..4310260 + 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T219403 WP_004205323.1 NZ_CP084783:c4305222-4304812 [Klebsiella quasipneumoniae subsp. similipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219403 NZ_CP116405:2713164-2713271 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219403 WP_002916312.1 NZ_CP084783:c4305469-4305203 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219403 NZ_CP116405:c2713117-2713051 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References