Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 494676..495189 Replicon chromosome
Accession NZ_CP084783
Organism Klebsiella quasipneumoniae subsp. similipneumoniae strain 09A323

Toxin (Protein)


Gene name relE Uniprot ID A0A663BE04
Locus tag LGM26_RS02340 Protein ID WP_017900571.1
Coordinates 494908..495189 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LGM26_RS02335 Protein ID WP_002886901.1
Coordinates 494676..494918 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM26_RS02320 (490706) 490706..491446 + 741 WP_017900574.1 KDGP aldolase family protein -
LGM26_RS02325 (491514) 491514..492665 + 1152 WP_017900573.1 lactonase family protein -
LGM26_RS02330 (492688) 492688..494598 + 1911 WP_017900572.1 PRD domain-containing protein -
LGM26_RS02335 (494676) 494676..494918 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LGM26_RS02340 (494908) 494908..495189 + 282 WP_017900571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM26_RS02345 (495193) 495193..495657 - 465 WP_004206512.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LGM26_RS02350 (495968) 495968..498106 - 2139 WP_004206513.1 anaerobic ribonucleoside-triphosphate reductase -
LGM26_RS02355 (498492) 498492..500147 - 1656 WP_017900569.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(18-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11082.93 Da        Isoelectric Point: 10.4123

>T219391 WP_017900571.1 NZ_CP084783:494908-495189 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDRVVVVYVIAIGKR
EKAAVYHQANKRL

Download         Length: 282 bp

>T219391 NZ_CP116404:1580910-1581179 [Burkholderia pseudomallei]
ATGGACATCACCTTTGACCCGACCAAGAACAAAACGAACATTGCCAAGCATGGAGTGTCGTTGGCGCTTGCAGCGCAACT
CGACTGGTCGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCG
GCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGG
GAGGTCAAGAGCTATGTCGAGCAAGCGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT219391 WP_002886901.1 NZ_CP084783:494676-494918 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT219391 NZ_CP116404:1581163-1581447 [Burkholderia pseudomallei]
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGTCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACGGTGCGCTATGACGTCGACATTGTCGACGCCTTCAAAGCGACGGGCGAAGGTTGGCAGACGCGTATG
AATGATGCGTTGCGCGAGTGGCTGAGGGAACATCAGCCTGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663BE04

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References