Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4558536..4559049 Replicon chromosome
Accession NZ_CP084779
Organism Klebsiella quasipneumoniae subsp. similipneumoniae strain 12A476

Toxin (Protein)


Gene name relE Uniprot ID A0A5Q9LKU5
Locus tag LGM27_RS22095 Protein ID WP_048322786.1
Coordinates 4558536..4558817 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LGM27_RS22100 Protein ID WP_002886901.1
Coordinates 4558807..4559049 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM27_RS22080 (4553578) 4553578..4555233 + 1656 WP_064183835.1 alpha,alpha-phosphotrehalase -
LGM27_RS22085 (4555619) 4555619..4557757 + 2139 WP_004206513.1 anaerobic ribonucleoside-triphosphate reductase -
LGM27_RS22090 (4558068) 4558068..4558532 + 465 WP_050533674.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LGM27_RS22095 (4558536) 4558536..4558817 - 282 WP_048322786.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM27_RS22100 (4558807) 4558807..4559049 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LGM27_RS22105 (4559127) 4559127..4561037 - 1911 WP_064183834.1 PRD domain-containing protein -
LGM27_RS22110 (4561060) 4561060..4562211 - 1152 WP_017900573.1 lactonase family protein -
LGM27_RS22115 (4562279) 4562279..4563019 - 741 WP_004206507.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(18-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11013.82 Da        Isoelectric Point: 10.2849

>T219389 WP_048322786.1 NZ_CP084779:c4558817-4558536 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGKR
EKAAVYHQANKRL

Download         Length: 282 bp

>T219389 NZ_CP116398:c3435049-3434753 [Methylomonas sp. EFPC3]
ATGTACACAATCAAACAACTCCCCGCATTCAGCGAATGGCTGTTTGGCTTGAAAGATGGATTGACGCACCGCCGGTTGGC
GCGCCGACTGGAAAAAGCACAACAAGGCAATCTCGGCGACGTGAAAGCGGTAGGCGAGGGTGTTTTTGAAATGCGTGAAC
ATTTCGGTCCCGGCTGGCGAATGTACTACGTGCAGCGGGGCGAGGTGTTGATTGTGATGCTGGGCGGCGGCGATAAATCT
AGTCAGGCTGCCGATATTGCCAAAGCTCAGTGCCTAGCCGCGTTGTTGGAGGACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT219389 WP_002886901.1 NZ_CP084779:c4559049-4558807 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT219389 NZ_CP116398:c3434749-3434444 [Methylomonas sp. EFPC3]
ATGAATGAAAAAATCAAAATCGCCGACTTACCCGTGTTTGACATTACCGAACATCTGGATAGCGATCAAGCCATTGCCGA
ATACCTGACCGTGGTTCTGGAAGAAGATGACCCGGCGGCCTTGGCTCACGCACTCGGCAGCATTGCCAGAGCGCGAGGCA
TGACCGAAATTGCCAATGCCGCCGGCATCAGCCGCGAGGCTTTGTATAAAGCCTTGCGTGCCGACGCCCAACCCCGCTTC
GAGACTATCGCCAAAGTTTGTAAGGCGCTTGGGGTTAAGTTGACGGTGCAGACGAGAGCGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LKU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References