Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2588003..2589591 | Replicon | chromosome |
| Accession | NZ_CP084779 | ||
| Organism | Klebsiella quasipneumoniae subsp. similipneumoniae strain 12A476 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A5Q9LEV0 |
| Locus tag | LGM27_RS12660 | Protein ID | WP_043519554.1 |
| Coordinates | 2588003..2589325 (-) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | LGM27_RS12665 | Protein ID | WP_136073472.1 |
| Coordinates | 2589325..2589591 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGM27_RS12625 (2583114) | 2583114..2583332 | + | 219 | WP_002904808.1 | ParD-like family protein | - |
| LGM27_RS12630 (2583313) | 2583313..2584095 | + | 783 | WP_049003659.1 | type I methionyl aminopeptidase | - |
| LGM27_RS26775 (2584364) | 2584364..2584891 | + | 528 | WP_267461597.1 | serine hydrolase domain-containing protein | - |
| LGM27_RS26780 (2584929) | 2584929..2585450 | + | 522 | WP_267461598.1 | serine hydrolase domain-containing protein | - |
| LGM27_RS12640 (2585437) | 2585437..2585781 | + | 345 | WP_004205915.1 | hypothetical protein | - |
| LGM27_RS12645 (2585810) | 2585810..2586343 | + | 534 | WP_004205916.1 | hypothetical protein | - |
| LGM27_RS12650 (2586346) | 2586346..2586552 | + | 207 | WP_004205917.1 | helix-turn-helix transcriptional regulator | - |
| LGM27_RS12655 (2586694) | 2586694..2587986 | + | 1293 | WP_048324186.1 | glycoside hydrolase family 10 protein | - |
| LGM27_RS12660 (2588003) | 2588003..2589325 | - | 1323 | WP_043519554.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| LGM27_RS12665 (2589325) | 2589325..2589591 | - | 267 | WP_136073472.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| LGM27_RS12670 (2589874) | 2589874..2590200 | - | 327 | WP_053810395.1 | hydroxyisourate hydrolase | - |
| LGM27_RS12675 (2590197) | 2590197..2590697 | - | 501 | WP_017900378.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| LGM27_RS12680 (2590675) | 2590675..2592054 | - | 1380 | WP_017900377.1 | nucleobase:cation symporter-2 family protein | - |
| LGM27_RS12685 (2592400) | 2592400..2593554 | + | 1155 | WP_043519552.1 | FAD-dependent urate hydroxylase HpxO | - |
| LGM27_RS12690 (2593535) | 2593535..2594458 | - | 924 | WP_004205929.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 48998.30 Da Isoelectric Point: 8.2655
>T219386 WP_043519554.1 NZ_CP084779:c2589325-2588003 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARQTLPSDFSAHVWRAITENMLKLHARLQQGLLAG
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARQTLPSDFSAHVWRAITENMLKLHARLQQGLLAG
Download Length: 1323 bp
>T219386 NZ_CP116398:c1952850-1952590 [Methylomonas sp. EFPC3]
GTGAAAATCACTTTTTCCTCCGACGCCTGGGATAGCTATCTCTACTGGCAAGCCACCGACAAGGCCATTCTCAAACGTAT
CAACCAATTGATCAAAGAAATCCAGCGCCAGCCCTTCGAGGGCATCGGTAAGCCGGAACCTTTGCAACACGGTTTGTCCG
GCTATTGGTCGCGGCGAATTAACGACGAGCATCGAATCGTTTATAAAGTTGCCGGGGATACCTTGTTGATTGCGCAGTTG
CGGTTTCATTATGAGTATTGA
GTGAAAATCACTTTTTCCTCCGACGCCTGGGATAGCTATCTCTACTGGCAAGCCACCGACAAGGCCATTCTCAAACGTAT
CAACCAATTGATCAAAGAAATCCAGCGCCAGCCCTTCGAGGGCATCGGTAAGCCGGAACCTTTGCAACACGGTTTGTCCG
GCTATTGGTCGCGGCGAATTAACGACGAGCATCGAATCGTTTATAAAGTTGCCGGGGATACCTTGTTGATTGCGCAGTTG
CGGTTTCATTATGAGTATTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9980.41 Da Isoelectric Point: 7.3163
>AT219386 WP_136073472.1 NZ_CP084779:c2589591-2589325 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIH
DNTTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIH
DNTTDLDW
Download Length: 267 bp
>AT219386 NZ_CP116398:c1953098-1952847 [Methylomonas sp. EFPC3]
ATGGACGCCATCAGTTACAGCGCCGCTCGCGCCAATTTGGCTAAAACCATGGACAAGGTTTGCGCCGACCATGCCCCCAT
CATCATCACCCGCAAAAGCGAATCCCCGGTGGTAATGCTGTCTCTGGAAGACTACCAAGCCATGGAGGAAACCGCCTACC
TGCTACGTTCCCCAGCTAACGCCCGCCGCTTGCTGGAATCGATCGCCGAGCTGGAATCCGGCCAAGGCACGGAGCGCGAA
TTAATCGAGTGA
ATGGACGCCATCAGTTACAGCGCCGCTCGCGCCAATTTGGCTAAAACCATGGACAAGGTTTGCGCCGACCATGCCCCCAT
CATCATCACCCGCAAAAGCGAATCCCCGGTGGTAATGCTGTCTCTGGAAGACTACCAAGCCATGGAGGAAACCGCCTACC
TGCTACGTTCCCCAGCTAACGCCCGCCGCTTGCTGGAATCGATCGCCGAGCTGGAATCCGGCCAAGGCACGGAGCGCGAA
TTAATCGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|