Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1579714..1581506 Replicon chromosome
Accession NZ_CP084779
Organism Klebsiella quasipneumoniae subsp. similipneumoniae strain 12A476

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LGM27_RS07675 Protein ID WP_064178420.1
Coordinates 1580157..1581506 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LGM27_RS07670 Protein ID WP_064178387.1
Coordinates 1579714..1580160 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM27_RS07655 (1576009) 1576009..1577007 + 999 WP_004201626.1 galactose/glucose ABC transporter substrate-binding protein MglB -
LGM27_RS07660 (1577126) 1577126..1578646 + 1521 WP_004201625.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
LGM27_RS07665 (1578662) 1578662..1579672 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
LGM27_RS07670 (1579714) 1579714..1580160 - 447 WP_064178387.1 helix-turn-helix transcriptional regulator Antitoxin
LGM27_RS07675 (1580157) 1580157..1581506 - 1350 WP_064178420.1 HipA domain-containing protein Toxin
LGM27_RS07680 (1581621) 1581621..1582352 - 732 WP_008804033.1 outer membrane permeability protein SanA -
LGM27_RS07685 (1582628) 1582628..1583512 - 885 WP_017899328.1 cytidine deaminase -
LGM27_RS07690 (1583641) 1583641..1584336 - 696 WP_004201621.1 CidB/LrgB family autolysis modulator -
LGM27_RS07695 (1584326) 1584326..1584730 - 405 WP_004201620.1 CidA/LrgA family protein -
LGM27_RS07700 (1585088) 1585088..1586020 + 933 WP_021313273.1 tRNA dihydrouridine(16) synthase DusC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-410)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51050.94 Da        Isoelectric Point: 4.8038

>T219377 WP_064178420.1 NZ_CP084779:c1581506-1580157 [Klebsiella quasipneumoniae subsp. similipneumoniae]
METLTVQAFLNAEWQDIALIKFPGSEQGDWFTTQIDYLTDYAIDFLERDDYHAVSLNHPVSLYFEDHGNPGWLRFIDDII
PSGASRRYWVNFLDISELPQGQQNFILLKFGTMSPVGNLRIKDSVPDWDSLASSKTFSVTDVMNRASDFLDYAQERGAAA
GGATGAGGEAPKLLLRCSKRQEIWIDTWQNEPGSDDLYYLVKYPRGSRSEVDCNILRAEFHYYHELTAMGFSTIPVDNMR
LEEGLHYPSLWLPRFDIRRDGDGRIMRLGMESVYSLLQKAPATILDHETTLRILIEKITSSHMVRVQNYRFDVQGFIIDW
VRRDLLNIIFGNSDNHGRNTAFMKADNEITLAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWIAPDT
LLNALRETASQLIDLPSRLKARGVPVQILEMPSIGFKFIPDKLARWGLL

Download         Length: 1350 bp

>T219377 NZ_CP116393:c243871-243095 [Streptococcus suis]
ATGAGGTTGGAAGAATTTAGTGAGGCTGACTTTCAGAAGGCCTTGCAGCGAACCATTCGGGTCTTAACCCGAGGAAAGAC
GATTCCAGGTCAACCGAAAGCTATCCTGCTTGGTGGACAAAGCGGGGCAGGTAAGACAACGGTACATCGTATCAAGCAGA
AGGAATTTCAAGGTAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAGCATCCCAATTACTTAGCCCTGCAAGAA
AAGTATGGCAAAGACAGCGTGGACCATACCAAGGGATTTGCAGGAAAAATGGTAGAACATCTGGTTGACGAACTAAGCAT
GCAAGGCTATCATTTGCTGATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGCTTCGA
AAGGATACCAAGTTTCCTTAGCTGTGATTGGTACCAAACCAGAATTGTCCTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGCCATCGATCCCAATCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTTGAGAACTTGGTTGATAA
CTTGAGGGAGTTAGAAAGAGAGCAACTCTTTGACTGTATTCAGATTTATCAAAGAGACAGAACTTGCATTTATGATTCTA
AAACGGATGAAGGTTCCGCAGCAGAAGTGTTACAAGAATGCCTCTTTGGAAAATGGAGTAAAGTCGAGGAGGAGATGATG
AAGTTTGGACAGGAACGGTTGTGGGAGATGAGTAAAAGTAATGGAAACGATGTATAG

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16510.20 Da        Isoelectric Point: 10.5137

>AT219377 WP_064178387.1 NZ_CP084779:c1580160-1579714 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MKTLNKKETEIQNTLARLRAENPPSLPATEVTATEKKARSEISRQRVSTGLKKVKTIDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIFKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp

>AT219377 NZ_CP116393:c244347-243871 [Streptococcus suis]
ATGATCGGAGACAATATAAAATCACTACGCCAGACACACGATTTAACACAACCAGAATTTGCGAAAATGGTTGGTATTTC
ACGCAATAGCCTGAGTCGCTACGAAAATGGAACTAGCACCGTTTCAACAGAACTCATTGACCGCATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGGGAGGACAAGATGTTAACACCTGTTGAAGATTACCAATTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCAAGATATTGCTTTTGATGATGA
AACAAATCCTTGGATTCTCATGAGCGATGATTTGGCTGAATTGATCAATACGCAAATTTATTTAGTTGACACCTTCGATG
AAATTGAGCGTTACAATGGCTATTTAGACGGTATTGAGCGGATGTTAGATATGGTACATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References