Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 767447..768104 Replicon chromosome
Accession NZ_CP084779
Organism Klebsiella quasipneumoniae subsp. similipneumoniae strain 12A476

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag LGM27_RS03775 Protein ID WP_004205323.1
Coordinates 767694..768104 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM27_RS03770 Protein ID WP_002916312.1
Coordinates 767447..767713 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM27_RS03745 (762656) 762656..764089 - 1434 WP_049004121.1 6-phospho-beta-glucosidase BglA -
LGM27_RS03750 (764208) 764208..764936 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
LGM27_RS03755 (764986) 764986..765297 + 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
LGM27_RS03760 (765460) 765460..766119 + 660 WP_004205319.1 hemolysin III family protein -
LGM27_RS03765 (766218) 766218..767201 - 984 WP_017899798.1 tRNA-modifying protein YgfZ -
LGM27_RS03770 (767447) 767447..767713 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM27_RS03775 (767694) 767694..768104 + 411 WP_004205323.1 protein YgfX Toxin
LGM27_RS03780 (768111) 768111..768632 - 522 WP_004205324.1 flavodoxin FldB -
LGM27_RS03785 (768733) 768733..769629 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM27_RS03790 (769652) 769652..770365 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM27_RS03795 (770371) 770371..772104 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T219376 WP_004205323.1 NZ_CP084779:767694-768104 [Klebsiella quasipneumoniae subsp. similipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219376 NZ_CP116392:1765473-1765754 [Brevibacterium sp. BDJS002]
GTGATCAGATCGTTTGCCGACCGCGACACCGAGCGTGTGTGGCGTCGTGAACCGGCGAGGCGACTTGATCCTCGTATTCA
CAAGACTGCGAATCGGAAGTTGCATCAGCTGGATGCAGCGGTGTCGCTCGATTCCATGCGTGTTCCGCCCGGTAATCGTC
TGGAGTCACTCAGAGGTGATCGGGCTGGTCAGCATAGCATTCGCATCAACGATCAGTGGCGGATCTGCTTTAGGTGGACC
GGTGCCGGTGCAGAAGAAGTCGAGATCGTGGACTATCACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219376 WP_002916312.1 NZ_CP084779:767447-767713 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219376 NZ_CP116392:1765764-1766063 [Brevibacterium sp. BDJS002]
ATGTCCGAGAAGCTTTACCCGCCGATCCATCCGGGGGAAGTCCTCATGGAGGATTTCATCGAGGGGTTCGGTATCACGCA
GAATAAGCTCGCTGTGTCGATCGGTGTGCCACCTCGGCGTATCAATGAAATAGTGCACGGAAAGCGTGCCATCACTGCCG
ACACAGCTTTGCGTTTGGGGCGGTATTTCGGTGTGGAGCCGCAATTCTGGCTTAACCTGCAGAGTCGTTATGATCTGGAG
CTTGCAGAGGAACGCGTGTCCGACCAGGTCGCGGCAATCACGCCGCTTAAGGTTGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References