Detailed information of TA system TA219373

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4692438..4692954
• Replicon: chromosome
• Accession: NZ_CP084777
• Organism: Klebsiella quasipneumoniae subsp. similipneumoniae strain CIP110288

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LGM28_RS22700
• Protein ID: WP_004206511.1
• Coordinates: 4692438..4692722 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: LGM28_RS22705
• Protein ID: WP_002886901.1
• Coordinates: 4692712..4692954 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGM28_RS22685 (4687480)	4687480..4689135	+	1656	WP_004206514.1	alpha,alpha-phosphotrehalase	-
LGM28_RS22690 (4689521)	4689521..4691659	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
LGM28_RS22695 (4691970)	4691970..4692434	+	465	WP_004206512.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LGM28_RS22700 (4692438)	4692438..4692722	-	285	WP_004206511.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LGM28_RS22705 (4692712)	4692712..4692954	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LGM28_RS22710 (4693032)	4693032..4694942	-	1911	WP_004206509.1	PRD domain-containing protein	-
LGM28_RS22715 (4694965)	4694965..4696116	-	1152	WP_004206508.1	lactonase family protein	-
LGM28_RS22720 (4696184)	4696184..4696924	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11163.01 Da
• Isoelectric Point: 10.4599

>T219373 WP_004206511.1 NZ_CP084777:c4692722-4692438 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCDKIKLKASGYRLVYQVRDRVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T219373 NZ_CP116387:448970-449359 [Acinetobacter baumannii]
TTGCTCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATAAGCTTTATTTTCTTTT
TAAAGCGTCCGCAACTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT219373 WP_002886901.1 NZ_CP084777:c4692954-4692712 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT219373 NZ_CP116387:448706-448963 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0