Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3961714..3962333 Replicon chromosome
Accession NZ_CP084777
Organism Klebsiella quasipneumoniae subsp. similipneumoniae strain CIP110288

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LGM28_RS19285 Protein ID WP_002892050.1
Coordinates 3962115..3962333 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LGM28_RS19280 Protein ID WP_002892066.1
Coordinates 3961714..3962088 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM28_RS19270 (3956867) 3956867..3958060 + 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LGM28_RS19275 (3958083) 3958083..3961229 + 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit AcrB -
LGM28_RS19280 (3961714) 3961714..3962088 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LGM28_RS19285 (3962115) 3962115..3962333 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LGM28_RS19290 (3962492) 3962492..3963058 + 567 WP_004204750.1 maltose O-acetyltransferase -
LGM28_RS19295 (3963030) 3963030..3963152 - 123 WP_032426076.1 hypothetical protein -
LGM28_RS19300 (3963195) 3963195..3963665 + 471 WP_004204751.1 YlaC family protein -
LGM28_RS19305 (3963634) 3963634..3965091 - 1458 WP_032455644.1 PLP-dependent aminotransferase family protein -
LGM28_RS19310 (3965192) 3965192..3965890 + 699 WP_060656954.1 GNAT family protein -
LGM28_RS19315 (3965887) 3965887..3966027 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LGM28_RS19320 (3966027) 3966027..3966290 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T219372 WP_002892050.1 NZ_CP084777:3962115-3962333 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T219372 NZ_CP116384:c1455107-1453800 [Vibrio sp. SCSIO 43137]
ATGCAAGAGTTAATAGCCTATATGAATGGAGAGCTTGTCGGCAGGTTGAAGAAGCAGTCAAACGGTGCTCATTCATTTCA
ATATGATTCCGACTGGATAACAAACAGTAAAGCCCGTCCTCTGTCCCTATCGCTTAAACTGCAACTTCCCCGAATAAACT
CAGACGCAGTCATTAATTATTTTGATAACCTGTTGCCTGATGCGCCAAAGGTTAGAGAAAGAATCGTAACCAGATATAAA
GCTTCGTCTATTCAACCATTTGATCTTCTGAAAGAAGTGGGTAAAGACAGTGTTGGTGCAATCACCCTTTTACCACCTGA
TAAGCCGTATAAAGAAGAACCGATAAGCTACAAGGTTTTAGATGAAGATAAGCTGGAAAATGTTCTTCTGGCATACAAGT
CAGAGATTCCTCTGGGAATGCTGGAGGAAGAAGAGGACTTCAGGATTTCTGTAGCGGGTGTACAGGAAAAAACAGCTCTT
CTTCGTTTTAATGATCAATGGTGTATACCTGAAGGAAACACACCGACCACCCACATTATCAAGCTTCCTATTGGTGAGAT
ACAACAAGCGCATGCAACACTGGATCTAACGGACAGTGTGGAAAACGAATACCTCTGTATTGAACTGGCAAGAGAGCTTG
GTTTTGACGTTCCTGAGATTGAAATGATACAGGTGAAGAGTGTGAAAGCTTTGGCTGTGGAACGTTTTGACAGGCGTTGG
AACCGGGATAGAACTAAGGTGTTGCGTTTACCTCAGGAAGATATTTGTCAGGTTTATGGAAAGCCTCCGTCGATAAAGTA
TGAATTTCAGGGAGGCCCCGGTATTGCTGAAATAATGAAGCTGTTAATGGGATCCAGTAATGCTCTGGACGATCAATATA
ATTTTATGAAGTTTCAGGTTTTTCAATGGGCAATTGGTGCTACGGACGGGCATGCAAAGAACTACTCAATTTATATAGAA
AAGGGCGGTAGCTACAGGCTCACTCCTTTTTATGACATCTTATCTGCTTATGTTGTCCTTGGTGGGAAAGGGCTAAATAT
CAGAAAACTGAAGTTAGCAATGGGGCTAAAAGCCACTAAAGGTAAGAAGTATGAGATCAATAAAATCTACGCTCATCACT
TTTTAGATACTGCAAAATCTGTCGGGTTTAATCAGGATAAAATGCAAATCATCTTAGACGATATACAAGTCGATCTTCCT
GAAGCCATTGAACGAGTAAGAGGAAGGTTGCCAAAGGATTTCCCTGATCATGTTGCTGAAGCCATATTCGGAAACTCTCT
GAAAATGGTTAAAAAGCTGGCAATGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT219372 WP_002892066.1 NZ_CP084777:3961714-3962088 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT219372 NZ_CP116384:c1455352-1455107 [Vibrio sp. SCSIO 43137]
ATGATATACAGTCCAAAGCAACTTGCTGACAGAATACTTCTCATACGGCAACAAAATAACTGGAGCCAAAGTGAACTTGC
AAAAAAGGTTGGTATAAAACAGGCAACCATTTCCAACTTTGAAAATAACCCTAGCCGGACTACCCTCGCTACTTTTTTCA
AATTGCTTCAGGCAATGGACTTAGTATTAACTGTTGATGAAAAAAGCCAGAACCAGACAAGTACTCCCGATGATGAGGAC
TGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References