Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 788765..789422 Replicon chromosome
Accession NZ_CP084777
Organism Klebsiella quasipneumoniae subsp. similipneumoniae strain CIP110288

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag LGM28_RS03890 Protein ID WP_004205323.1
Coordinates 789012..789422 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM28_RS03885 Protein ID WP_002916312.1
Coordinates 788765..789031 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM28_RS03860 (783974) 783974..785407 - 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -
LGM28_RS03865 (785526) 785526..786254 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
LGM28_RS03870 (786304) 786304..786615 + 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
LGM28_RS03875 (786778) 786778..787437 + 660 WP_004205319.1 hemolysin III family protein -
LGM28_RS03880 (787536) 787536..788519 - 984 WP_017899798.1 tRNA-modifying protein YgfZ -
LGM28_RS03885 (788765) 788765..789031 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM28_RS03890 (789012) 789012..789422 + 411 WP_004205323.1 protein YgfX Toxin
LGM28_RS03895 (789429) 789429..789950 - 522 WP_004205324.1 flavodoxin FldB -
LGM28_RS03900 (790051) 790051..790947 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM28_RS03905 (790970) 790970..791683 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM28_RS03910 (791689) 791689..793422 + 1734 WP_136084845.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T219362 WP_004205323.1 NZ_CP084777:789012-789422 [Klebsiella quasipneumoniae subsp. similipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219362 NZ_CP116350:3575-4099 [Enterobacter ludwigii]
GTGGCCAACCTGACCATTGAGATGTTTTCAGAAGAGGCTGTATATGATTTCTCATGCTTCGACTGCGGAGAAACGTCTCT
CAATGATTTTCTTAACAATCGCCTCGCCCAGCAACACAGCGGGCGTATATTACGCGGATATCTGCTTCTGACGAGAGATC
CGATACCGAAAGTGATGGGGTTTTACACGTTGTCCGGGAGCTGCTTTGCAAGAAACACGCTTCCTTCCAACACTCAACAG
CGTAAAGTCCCCTATTCCGACGCCCCAAGCGTTACGCTCGGTCGTCTGGCAATAGACAAAAGTATCCAGCGACAAGGGTA
TGGGGAAACGCTGGTGGCACATGCGATGAAAGTGGTATACCGGGCTTCCCTGGCCGTTGGGATCTACGCTTTGTTTGTTG
ACGCCAAAAATGAGAATGCGATGCGGTTTTATAAGCAGTTAGGCTTTACCCCTCTTACGGGTGATAACGCCAATTCGCTG
TTCTATCCCACAAAAGGCATTGAGAAGTTGTTTGGTGGAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219362 WP_002916312.1 NZ_CP084777:788765-789031 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219362 NZ_CP116350:3302-3571 [Enterobacter ludwigii]
ATGTCCGCACTGAAAAAACAGCGCATCGATCTCAGATTAACCGACGACGACAAGAGCATGATCGAAGAAGCTGCGGCAAT
GACCAACCAGACAATTACTCAGTTTATGGTTGCCAGTGCCTCTGAACGTGCTGCGGAAGTGATAGAGCAACATCGCCGCT
TGATTCTCAGTGAAGAGTCCTGGAATCTGGTAATGGATGCAATCAGTAACCCGCCTGCACCGAACGATAGGCTGAAACGA
GCTGCCAAGCGTCTACAAAGCATGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References