Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 145837..146747 Replicon plasmid pKqs_SB610_1
Accession NZ_CP084771
Organism Klebsiella quasipneumoniae subsp. similipneumoniae strain SB610

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag LGM29_RS26335 Protein ID WP_004026354.1
Coordinates 146277..146747 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag LGM29_RS26330 Protein ID WP_004181895.1
Coordinates 145837..146280 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM29_RS26310 (LGM29_26310) 141114..141821 + 708 WP_004181864.1 hypothetical protein -
LGM29_RS26315 (LGM29_26315) 141826..142857 + 1032 WP_029505552.1 hypothetical protein -
LGM29_RS26320 (LGM29_26320) 144043..144465 + 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
LGM29_RS26325 (LGM29_26325) 144465..145736 + 1272 WP_004181894.1 translesion error-prone DNA polymerase V subunit UmuC -
LGM29_RS26330 (LGM29_26330) 145837..146280 + 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
LGM29_RS26335 (LGM29_26335) 146277..146747 + 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
LGM29_RS26340 (LGM29_26340) 146857..147117 - 261 WP_004026352.1 hypothetical protein -
LGM29_RS26345 (LGM29_26345) 147816..149185 + 1370 WP_085956500.1 IS3-like element ISKpn8 family transposase -
LGM29_RS26350 (LGM29_26350) 149182..150315 - 1134 WP_049245444.1 IS481 family transposase -
LGM29_RS29740 150387..150545 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..224856 224856


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T219357 WP_004026354.1 NZ_CP084771:146277-146747 [Klebsiella quasipneumoniae subsp. similipneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T219357 NZ_CP116347:c3012743-3012640 [Enterobacter ludwigii]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT219357 WP_004181895.1 NZ_CP084771:145837-146280 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT219357 NZ_CP116347:3012626-3012778 [Enterobacter ludwigii]
GCTTTCAATCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCG
CTAAAAGTTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References