Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4650693..4651206 Replicon chromosome
Accession NZ_CP084770
Organism Klebsiella quasipneumoniae subsp. similipneumoniae strain SB610

Toxin (Protein)


Gene name relE Uniprot ID A0A663BE04
Locus tag LGM29_RS22680 Protein ID WP_017900571.1
Coordinates 4650693..4650974 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LGM29_RS22685 Protein ID WP_002886901.1
Coordinates 4650964..4651206 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM29_RS22665 (4647351) 4647351..4647509 + 159 WP_017900570.1 hypothetical protein -
LGM29_RS22670 (4647704) 4647704..4649842 + 2139 WP_153669840.1 anaerobic ribonucleoside-triphosphate reductase -
LGM29_RS22675 (4650225) 4650225..4650689 + 465 WP_032456904.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LGM29_RS22680 (4650693) 4650693..4650974 - 282 WP_017900571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM29_RS22685 (4650964) 4650964..4651206 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LGM29_RS22690 (4651284) 4651284..4653194 - 1911 WP_032456902.1 PRD domain-containing protein -
LGM29_RS22695 (4653217) 4653217..4654368 - 1152 WP_226548948.1 lactonase family protein -
LGM29_RS22700 (4654435) 4654435..4655175 - 741 WP_004206507.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(18-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11082.93 Da        Isoelectric Point: 10.4123

>T219356 WP_017900571.1 NZ_CP084770:c4650974-4650693 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDRVVVVYVIAIGKR
EKAAVYHQANKRL

Download         Length: 282 bp

>T219356 NZ_CP116347:c1104496-1104278 [Enterobacter ludwigii]
ATGTCTGAAAAACCACTCACAAAAATCGATTATTTGATGCGTTTGCGACGCTGCCAGTCAATAGACACGCTTGAACGTGT
AATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCGGCTGACCACCGTCTTGCAGAAC
TGACCATGAATAAGCTGTATGACAAAATCCCAACGTCCGTGTGGAGATTTGTCCGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT219356 WP_002886901.1 NZ_CP084770:c4651206-4650964 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT219356 NZ_CP116347:c1104898-1104524 [Enterobacter ludwigii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTAAACGAGTTGATCGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGATGAATACCTG
GATGACACCTTTATGTTGTTCAGCAGCTACGGCATTAATGCGCAAGATTTGCAGAAATGGCGTAAATCGGGCAACCGACT
ATTTCGTTGCTTCATCAACGTGAGCAGAGCTAACCCCGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663BE04

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References