Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3961743..3962362 Replicon chromosome
Accession NZ_CP084770
Organism Klebsiella quasipneumoniae subsp. similipneumoniae strain SB610

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LGM29_RS19380 Protein ID WP_002892050.1
Coordinates 3962144..3962362 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LGM29_RS19375 Protein ID WP_002892066.1
Coordinates 3961743..3962117 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM29_RS19365 (3956896) 3956896..3958089 + 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LGM29_RS19370 (3958112) 3958112..3961258 + 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit AcrB -
LGM29_RS19375 (3961743) 3961743..3962117 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LGM29_RS19380 (3962144) 3962144..3962362 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LGM29_RS19385 (3962521) 3962521..3963087 + 567 WP_004204750.1 maltose O-acetyltransferase -
LGM29_RS19390 (3963059) 3963059..3963181 - 123 WP_032426076.1 hypothetical protein -
LGM29_RS19395 (3963224) 3963224..3963694 + 471 WP_004204751.1 YlaC family protein -
LGM29_RS19400 (3963663) 3963663..3965120 - 1458 WP_004204752.1 PLP-dependent aminotransferase family protein -
LGM29_RS19405 (3965221) 3965221..3965919 + 699 WP_226548738.1 GNAT family protein -
LGM29_RS19410 (3965916) 3965916..3966056 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LGM29_RS19415 (3966056) 3966056..3966319 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T219355 WP_002892050.1 NZ_CP084770:3962144-3962362 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T219355 NZ_CP116347:483552-483836 [Enterobacter ludwigii]
ATGACTTATGAACTCGTATTTGATCCGAGGGCGTTCAAGGAGTGGACCAGGCTGGGTGATACCGTAAAAAATCAGTTTAA
GAAGAAGCTTGCGAACGTGTTGGTGAACCCCTGGGTTGAATCGGCTCGCCTGCATGGCCTGCCTGATTGCGACAAGATAA
AACTCAGATCCCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAATGTTGTGACGGTATGTGTTATTACTATCGGTAAG
AGAGAGAAATCAGCCGTTTATCATGACGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT219355 WP_002892066.1 NZ_CP084770:3961743-3962117 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT219355 NZ_CP116347:483320-483562 [Enterobacter ludwigii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTTGAAAAACTCAATATCACGCC
AACGGAAGCCGTTCGGTTACTGTTTCAGTACGTTGCGGAGACGGGGCGTATGCCGGTGAAAACGGTCACTGTTAGCGACA
GTGAAGATGAACTCATACAGACAGTCCGGGAGCGGCTGGCTAATCCGCAAAAAGGAATTAAGGTTAGGCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References