Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 833722..834379 Replicon chromosome
Accession NZ_CP084770
Organism Klebsiella quasipneumoniae subsp. similipneumoniae strain SB610

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag LGM29_RS04130 Protein ID WP_004205323.1
Coordinates 833969..834379 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM29_RS04125 Protein ID WP_002916312.1
Coordinates 833722..833988 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM29_RS04100 (828925) 828925..830358 - 1434 WP_049004121.1 6-phospho-beta-glucosidase BglA -
LGM29_RS04105 (830477) 830477..831205 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
LGM29_RS04110 (831255) 831255..831566 + 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
LGM29_RS04115 (831729) 831729..832388 + 660 WP_004205319.1 hemolysin III family protein -
LGM29_RS04120 (832493) 832493..833476 - 984 WP_049116109.1 tRNA-modifying protein YgfZ -
LGM29_RS04125 (833722) 833722..833988 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM29_RS04130 (833969) 833969..834379 + 411 WP_004205323.1 protein YgfX Toxin
LGM29_RS04135 (834386) 834386..834907 - 522 WP_004205324.1 flavodoxin FldB -
LGM29_RS04140 (835008) 835008..835904 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM29_RS04145 (835927) 835927..836640 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM29_RS04150 (836646) 836646..838379 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T219345 WP_004205323.1 NZ_CP084770:833969-834379 [Klebsiella quasipneumoniae subsp. similipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219345 NZ_CP116318:412734-413318 [Bacillus thuringiensis]
TTGGCTAATAAAGATAATCCTAAATTCTACACCATTTCAACTGAATATATAGATTATTTAAGAGAAACGGATAGTAAAGT
ACCTTTTAATAAAGATGAACAGCATAGTAGACCGTATGTAGGTGTATTGGAAAAAATCAATGGTCATGATTATTTTGTAC
CTTTAACATCACGTAACGATAAAAATTTTAACAGTCAGGTCAGTGTGAAATTATTCGATACTGATGAAAAGCGAATTGGA
GTTTTATTGGTTAATAACATGATTCCAGTCCCAGAAAAAGAGTGTAAAGAAATTGATATAGCAGAAAAAACAGCAGCAGA
CCCTCAGTATGGTAATTTGATGTTAAAACAGTATTTATTTTTAAAAGAAAATATGGATCGAGTTACTAATAAAGTGGAAA
AAGTATATAAAGATGTAACTGTACAAGGAAAGCCTTCACATAAACAAAAATTCTTAAAAGGAGTTTGTTGTGATTTCCCT
AAATTAGAAGAAAAGTGCCAAGAATATAAAGAAAGAGATCAAGCTAAAGAAAGAGATAAAGCTAGAAGAATAGCATATAT
GCGTCAAATGGGGCGTGAGAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219345 WP_002916312.1 NZ_CP084770:833722-833988 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219345 NZ_CP116318:412576-412672 [Bacillus thuringiensis]
GTAACCTTACTTTAGTAGGTGCGAAAAAATTGGTGTAACTCTACCGTAGTGAGTACCAAAAAATTGGTGTAGCCTTACCG
TAGTAGGCGCTAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References