Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 4017795..4018385 Replicon chromosome
Accession NZ_CP084767
Organism Klebsiella variicola subsp. tropica strain CDC4241-71

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag LGN97_RS19390 Protein ID WP_074385360.1
Coordinates 4017795..4018127 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag LGN97_RS19395 Protein ID WP_136086128.1
Coordinates 4018128..4018385 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGN97_RS19355 (LGN97_19355) 4014106..4014264 - 159 WP_165784169.1 hypothetical protein -
LGN97_RS19360 (LGN97_19360) 4014870..4015223 + 354 WP_136086126.1 type II toxin-antitoxin system RelE/ParE family toxin -
LGN97_RS19365 (LGN97_19365) 4015228..4015530 + 303 WP_136086127.1 XRE family transcriptional regulator -
LGN97_RS19375 (LGN97_19375) 4016036..4017472 - 1437 WP_165784170.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
LGN97_RS19390 (LGN97_19390) 4017795..4018127 - 333 WP_074385360.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LGN97_RS19395 (LGN97_19395) 4018128..4018385 - 258 WP_136086128.1 antitoxin Antitoxin
LGN97_RS19400 (LGN97_19400) 4018913..4020013 + 1101 WP_100675340.1 AarF/UbiB family protein -
LGN97_RS19405 (LGN97_19405) 4020010..4020981 - 972 WP_061153976.1 sensor domain-containing diguanylate cyclase -
LGN97_RS19410 (LGN97_19410) 4021189..4022025 - 837 WP_064323654.1 alpha/beta hydrolase -
LGN97_RS19415 (LGN97_19415) 4022204..4022779 - 576 WP_136086129.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11904.78 Da        Isoelectric Point: 10.1840

>T219342 WP_074385360.1 NZ_CP084767:c4018127-4017795 [Klebsiella variicola subsp. tropica]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGHFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDAVINEVLARLDAILS

Download         Length: 333 bp

>T219342 NZ_CP116308:11538-12047 [Xanthomonas perforans]
ATGAAGGTATCAGCGCCCGAACCGCTGGCCGCGCACCACGACATTGAAGCCTTCGACTCCGGGGTGGACAGTCTGGACCA
GTGGCTAAAGCGTCGTGCCCTGAAAAATCAGGCTACCGGCGCTTCGCGAACCTTCGTCGCCTGCGACGATGGCCGCGTGG
TGGCCTACTATGCGCTGGCATCGAGCGGGGTCACGGTGGACGCAGCGCCCGGACGCTTCCGACGCAACATGCCGGACCCG
ATTCCGGTGGTGGTCCTTGGCAGGCTGGCCGTAGATCAATCGCAGCAGGGCAGGGGCCTAGGCCGCGCTCTGGTGAAAGA
TGCCGGGCAGCGCATCGTCCAAGCCGCCGACACCATCGGGATTCGCGGGGTGCTCGTGCATGCGCTCTCGGCCGACGCCA
AGGCGTTCTATGAGCGGATCGGCTTTGAGCCGTCGCCCCTCGATCCGATGATGCTGCTGGTCACGCTGGATGACCTGAAA
GCCAGCCTCGAACCGCAAGCCCGCCGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9483.00 Da        Isoelectric Point: 4.4915

>AT219342 WP_136086128.1 NZ_CP084767:c4018385-4018128 [Klebsiella variicola subsp. tropica]
MYKTRLKRVGGSIMLAVPPAVLKALELSTDSEVGMTIDNGCLIIEPQKRPHYSLEELLAQCDLHAEMSEEDREWIDAPAV
GKEIM

Download         Length: 258 bp

>AT219342 NZ_CP116308:11251-11541 [Xanthomonas perforans]
ATGCCCACGATGAGCACCGCACCCAGCAAGCGTGAAACGCTGAACATCCGCATCAAGCCCGAGGAACGGAGCTTGATCGA
CCGCGCCGCCAAGGCACGGGGCAAGAACCGCACCGACTTCGTGCTGGAAGCCGCCCGGTCGGCCGCCGAGGAAGCGTTAC
TAGACCAGACGATCATTTCCGCCAGCCCGGACGCCTACGCGGCCTTTCTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GAACGCCTGCGGAAAACCATGCAGACGCCCGCCCCGTGGGAGAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References