Detailed information of TA system TA219332

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3102454..3104042
• Replicon: chromosome
• Accession: NZ_CP084767
• Organism: Klebsiella variicola subsp. tropica strain CDC4241-71

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LGN97_RS14845
• Protein ID: WP_074385880.1
• Coordinates: 3102720..3104042 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A1F2MCN9
• Locus tag: LGN97_RS14840
• Protein ID: WP_008804920.1
• Coordinates: 3102454..3102720 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGN97_RS14815 (LGN97_14815)	3097604..3098527	+	924	WP_008804925.1	LysR family hpxDE operon transcriptional regulator HpxR	-
LGN97_RS14820 (LGN97_14820)	3098508..3099662	-	1155	WP_061154625.1	FAD-dependent urate hydroxylase HpxO	-
LGN97_RS14825 (LGN97_14825)	3100008..3101387	+	1380	WP_226682135.1	nucleobase:cation symporter-2 family protein	-
LGN97_RS14830 (LGN97_14830)	3101365..3101865	+	501	WP_074385882.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LGN97_RS14835 (LGN97_14835)	3101862..3102188	+	327	WP_100729694.1	hydroxyisourate hydrolase	-
LGN97_RS14840 (LGN97_14840)	3102454..3102720	+	267	WP_008804920.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LGN97_RS14845 (LGN97_14845)	3102720..3104042	+	1323	WP_074385880.1	type II toxin-antitoxin system HipA family toxin	Toxin
LGN97_RS14850 (LGN97_14850)	3104059..3105351	-	1293	WP_061154620.1	glycoside hydrolase family 10 protein	-
LGN97_RS14855 (LGN97_14855)	3105484..3106488	-	1005	WP_074385878.1	fimbrial protein	-
LGN97_RS14860 (LGN97_14860)	3106476..3108977	-	2502	WP_136085753.1	fimbria/pilus outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49182.58 Da
• Isoelectric Point: 7.9110

>T219332 WP_074385880.1 NZ_CP084767:3102720-3104042 [Klebsiella variicola subsp. tropica]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRDAFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKTVNFPREQMLAILHEFAERVP
QAIESARRTLPADFSAHVWRAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T219332 NZ_CP116303:1792495-1792752 [Tenacibaculum finnmarkense]
ATGAAGTATACATTCGTTGACGAGTCTTGGGAAGATTATTTGTATTGGCAAAAAACAGACAAAAAAAAGTTAAAAAAAAT
AAATGAACTTCTAAAAGACATTGCTCGAAATCCTTTTGATGGGATTGGAAAACCAGAAGCACTAAAACATAAATACGCAG
GATTTTGGTCAAGACGAATTGATAGTGAGCATAGATTGATTTACCAATATCGAGAAGGAGAAATCTTAATTGCCAAATGT
AGATTCCATTATAACTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.30 Da
• Isoelectric Point: 8.5912

>AT219332 WP_008804920.1 NZ_CP084767:3102454-3102720 [Klebsiella variicola subsp. tropica]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT219332 NZ_CP116303:1792239-1792493 [Tenacibaculum finnmarkense]
ATGCAAATAACAACTGTTTCTGACTTCAGAAAAGATATTAAAAGTTACTTAGACAGAGTTATCAAAGACTTTGAAACATT
AATAATAAATCGCGGAAAAGATGCTGGAATTGTAGTTATGTCATTGCAGGAATACAATTCTTTAATGGCTACAAATCATG
AATTATCTTCACGAAAAAATGAATTAAGATTAGACTCTGCAATTGACAAACTAAAAAACGGAATGACCTTAAACAAAGAC
CTAATCGAAAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A1F2MCN9