Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2650799..2652387 | Replicon | chromosome |
| Accession | NZ_CP084766 | ||
| Organism | Klebsiella variicola subsp. variicola strain 01A065 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A1F2MCM0 |
| Locus tag | LGN95_RS12860 | Protein ID | WP_008804919.1 |
| Coordinates | 2650799..2652121 (-) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A1F2MCN9 |
| Locus tag | LGN95_RS12865 | Protein ID | WP_008804920.1 |
| Coordinates | 2652121..2652387 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGN95_RS12845 (LGN95_12845) | 2645864..2648365 | + | 2502 | WP_050887168.1 | fimbria/pilus outer membrane usher protein | - |
| LGN95_RS12850 (LGN95_12850) | 2648353..2649357 | + | 1005 | WP_063105598.1 | fimbrial protein | - |
| LGN95_RS12855 (LGN95_12855) | 2649490..2650782 | + | 1293 | WP_016161010.1 | glycoside hydrolase family 10 protein | - |
| LGN95_RS12860 (LGN95_12860) | 2650799..2652121 | - | 1323 | WP_008804919.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| LGN95_RS12865 (LGN95_12865) | 2652121..2652387 | - | 267 | WP_008804920.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| LGN95_RS12870 (LGN95_12870) | 2652653..2652979 | - | 327 | WP_008804921.1 | hydroxyisourate hydrolase | - |
| LGN95_RS12875 (LGN95_12875) | 2652976..2653476 | - | 501 | WP_064170224.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| LGN95_RS12880 (LGN95_12880) | 2653454..2654833 | - | 1380 | WP_012968246.1 | nucleobase:cation symporter-2 family protein | - |
| LGN95_RS12885 (LGN95_12885) | 2655178..2656332 | + | 1155 | WP_008804924.1 | FAD-dependent urate hydroxylase HpxO | - |
| LGN95_RS12890 (LGN95_12890) | 2656313..2657236 | - | 924 | WP_008804925.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 48911.26 Da Isoelectric Point: 7.9109
>T219321 WP_008804919.1 NZ_CP084766:c2652121-2650799 [Klebsiella variicola subsp. variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T219321 NZ_CP116264:c462-175 [Aeromonas salmonicida subsp. salmonicida]
ATGACCTTTGAGCTTGAGTTCGACCCACGAGCGTGGAAGGAATGGAAGAAGTTGGGCGATACAGTTCGCCAGCAGTTCAA
AAAGAAGCTGGCAGAGGTGCTGGAGCGACCTAGGGTAGAGGCGAATCGTCTGCATGGGCTGCCGGACTGCTACAAGATTA
AGCTGCGTGGGGCTGGGTACCGGTTGGTGTATCAGGTACAGGATGATCGGGTGCTGGTCTTCGTGGTCGCAGTGGGTAAA
CGAGAGCGGGAGCAGGTGTATCTGGACGCTGGTTATCGGCTGGAATAG
ATGACCTTTGAGCTTGAGTTCGACCCACGAGCGTGGAAGGAATGGAAGAAGTTGGGCGATACAGTTCGCCAGCAGTTCAA
AAAGAAGCTGGCAGAGGTGCTGGAGCGACCTAGGGTAGAGGCGAATCGTCTGCATGGGCTGCCGGACTGCTACAAGATTA
AGCTGCGTGGGGCTGGGTACCGGTTGGTGTATCAGGTACAGGATGATCGGGTGCTGGTCTTCGTGGTCGCAGTGGGTAAA
CGAGAGCGGGAGCAGGTGTATCTGGACGCTGGTTATCGGCTGGAATAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 9936.30 Da Isoelectric Point: 8.5912
>AT219321 WP_008804920.1 NZ_CP084766:c2652387-2652121 [Klebsiella variicola subsp. variicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW
Download Length: 267 bp
>AT219321 NZ_CP116264:c694-452 [Aeromonas salmonicida subsp. salmonicida]
ATGGGGACGATTAACCTTCGCATCGATGATGAGCTGAAAACCCGCTCGTATGCGGTACTTGAACGACTTGGTGTAACTCC
ATCTGAGTTACTGCGACAAACTCTGGAATATGTGGCCTCTCAGGAACGACTGCCTTTTCGGACGACCGTGGTAACGGAGG
ATGAGGAGGCATTGCTTGTTCTTGTTCGTGAGCGGCTGGCCAGCCCCCAGAAAGGGATCAGGGTGTCGCTGGATGACCTT
TGA
ATGGGGACGATTAACCTTCGCATCGATGATGAGCTGAAAACCCGCTCGTATGCGGTACTTGAACGACTTGGTGTAACTCC
ATCTGAGTTACTGCGACAAACTCTGGAATATGTGGCCTCTCAGGAACGACTGCCTTTTCGGACGACCGTGGTAACGGAGG
ATGAGGAGGCATTGCTTGTTCTTGTTCGTGAGCGGCTGGCCAGCCCCCAGAAAGGGATCAGGGTGTCGCTGGATGACCTT
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1F2MCM0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1F2MCN9 |