Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 1860804..1861441 | Replicon | chromosome |
| Accession | NC_008800 | ||
| Organism | Yersinia enterocolitica subsp. enterocolitica 8081 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | YE_RS08355 | Protein ID | WP_005170069.1 |
| Coordinates | 1860804..1861208 (-) | Length | 135 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A0T9QJI8 |
| Locus tag | YE_RS08360 | Protein ID | WP_005170066.1 |
| Coordinates | 1861208..1861441 (-) | Length | 78 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| YE_RS08310 (YE1650) | 1856433..1856843 | + | 411 | WP_011816086.1 | phage tail protein | - |
| YE_RS08315 (YE1651) | 1856945..1857232 | + | 288 | WP_011816087.1 | hypothetical protein | - |
| YE_RS08320 (YE1652) | 1857369..1857551 | - | 183 | WP_011816088.1 | hypothetical protein | - |
| YE_RS08325 (YE1653) | 1857643..1857837 | - | 195 | WP_042661390.1 | hypothetical protein | - |
| YE_RS08330 (YE1654) | 1857891..1858259 | + | 369 | WP_011816090.1 | hypothetical protein | - |
| YE_RS08335 (YE1655) | 1858406..1859314 | - | 909 | WP_080326929.1 | Rpn family recombination-promoting nuclease/putative transposase | - |
| YE_RS08340 (YE1656) | 1859520..1859696 | - | 177 | WP_005170412.1 | hypothetical protein | - |
| YE_RS08345 (YE1657) | 1860141..1860461 | - | 321 | WP_011816092.1 | hypothetical protein | - |
| YE_RS08350 | 1860451..1860657 | - | 207 | WP_042661392.1 | host cell division inhibitor Icd-like protein | - |
| YE_RS08355 (YE1658) | 1860804..1861208 | - | 405 | WP_005170069.1 | tRNA(fMet)-specific endonuclease VapC | Toxin |
| YE_RS08360 (YE1659) | 1861208..1861441 | - | 234 | WP_005170066.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| YE_RS08365 (YE1661) | 1861923..1862537 | - | 615 | WP_011816093.1 | tail fiber assembly protein | - |
| YE_RS08370 (YE1662) | 1862537..1863665 | - | 1129 | Protein_1607 | phage tail protein | - |
| YE_RS08375 (YE1663) | 1863916..1864458 | - | 543 | WP_011816095.1 | phage tail protein I | - |
| YE_RS08380 (YE1664) | 1864451..1865359 | - | 909 | WP_011816096.1 | baseplate assembly protein | - |
| YE_RS08385 (YE1665) | 1865356..1865691 | - | 336 | WP_162484209.1 | GPW/gp25 family protein | - |
| YE_RS08390 (YE1666) | 1865703..1866341 | - | 639 | WP_042661393.1 | phage baseplate assembly protein V | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | pilW | 1845101..1893778 | 48677 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 135 a.a. Molecular weight: 14907.16 Da Isoelectric Point: 7.4667
>T21932 WP_005170069.1 NC_008800:c1861208-1860804 [Yersinia enterocolitica subsp. enterocolitica 8081]
MHKYMLDTNIVIYVIKRRPIEVLGRFNANAGRMVISSITLAELLHGVEKSAAPERNLSVVEDFVSRLTVLDYDDKAAIHY
GSIRASLEQKGTPIGVNDLHIAGHARSTGLILVTNNRKEFDRVPGLIVDNWLGE
MHKYMLDTNIVIYVIKRRPIEVLGRFNANAGRMVISSITLAELLHGVEKSAAPERNLSVVEDFVSRLTVLDYDDKAAIHY
GSIRASLEQKGTPIGVNDLHIAGHARSTGLILVTNNRKEFDRVPGLIVDNWLGE
Download Length: 405 bp
>T21932 NC_008800:c1861208-1860804 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGCATAAGTACATGCTCGATACGAATATCGTTATATATGTCATTAAACGCCGGCCTATAGAAGTGTTAGGTCGGTTTAA
CGCTAATGCGGGCAGAATGGTTATTTCTTCCATCACACTGGCTGAGTTATTGCATGGCGTAGAGAAAAGCGCGGCACCTG
AACGCAATTTAAGTGTTGTAGAGGATTTTGTTTCACGTCTTACTGTATTGGATTATGACGATAAAGCCGCAATTCACTAT
GGTTCTATACGTGCGAGTCTGGAGCAAAAAGGCACACCCATCGGTGTTAATGATTTGCATATCGCAGGTCATGCCAGAAG
CACCGGATTGATATTAGTGACCAATAATCGCAAAGAATTTGATCGTGTGCCTGGACTGATTGTCGACAACTGGCTAGGAG
AATAA
ATGCATAAGTACATGCTCGATACGAATATCGTTATATATGTCATTAAACGCCGGCCTATAGAAGTGTTAGGTCGGTTTAA
CGCTAATGCGGGCAGAATGGTTATTTCTTCCATCACACTGGCTGAGTTATTGCATGGCGTAGAGAAAAGCGCGGCACCTG
AACGCAATTTAAGTGTTGTAGAGGATTTTGTTTCACGTCTTACTGTATTGGATTATGACGATAAAGCCGCAATTCACTAT
GGTTCTATACGTGCGAGTCTGGAGCAAAAAGGCACACCCATCGGTGTTAATGATTTGCATATCGCAGGTCATGCCAGAAG
CACCGGATTGATATTAGTGACCAATAATCGCAAAGAATTTGATCGTGTGCCTGGACTGATTGTCGACAACTGGCTAGGAG
AATAA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8978.95 Da Isoelectric Point: 5.0351
>AT21932 WP_005170066.1 NC_008800:c1861441-1861208 [Yersinia enterocolitica subsp. enterocolitica 8081]
MSQGTIFTNNRTQNVRLPVDMRFPENVKSVTVRAVGNERILSPVENSWDSFFFSSPRVSDDFLTERAEQHQSERELF
MSQGTIFTNNRTQNVRLPVDMRFPENVKSVTVRAVGNERILSPVENSWDSFFFSSPRVSDDFLTERAEQHQSERELF
Download Length: 234 bp
>AT21932 NC_008800:c1861441-1861208 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGTCACAGGGCACCATTTTTACGAACAATCGTACTCAAAACGTGCGTTTACCAGTGGATATGCGCTTTCCAGAGAATGT
TAAATCAGTGACTGTGAGAGCTGTAGGGAATGAGCGTATCTTGTCACCCGTTGAAAACTCTTGGGATAGCTTTTTCTTCA
GTAGTCCGCGTGTTTCAGACGATTTTCTGACCGAACGCGCAGAACAGCATCAATCAGAGCGTGAGTTATTTTAA
ATGTCACAGGGCACCATTTTTACGAACAATCGTACTCAAAACGTGCGTTTACCAGTGGATATGCGCTTTCCAGAGAATGT
TAAATCAGTGACTGTGAGAGCTGTAGGGAATGAGCGTATCTTGTCACCCGTTGAAAACTCTTGGGATAGCTTTTTCTTCA
GTAGTCCGCGTGTTTCAGACGATTTTCTGACCGAACGCGCAGAACAGCATCAATCAGAGCGTGAGTTATTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|