Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 778855..779512 Replicon chromosome
Accession NZ_CP084766
Organism Klebsiella variicola subsp. variicola strain 01A065

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LGN95_RS03850 Protein ID WP_002916310.1
Coordinates 779102..779512 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGN95_RS03845 Protein ID WP_002916312.1
Coordinates 778855..779121 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGN95_RS03825 (LGN95_03825) 775298..776026 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
LGN95_RS03830 (LGN95_03830) 776077..776388 + 312 WP_109848735.1 N(4)-acetylcytidine aminohydrolase -
LGN95_RS03835 (LGN95_03835) 776552..777211 + 660 WP_008806429.1 hemolysin III family protein -
LGN95_RS03840 (LGN95_03840) 777626..778609 - 984 WP_012967246.1 tRNA-modifying protein YgfZ -
LGN95_RS03845 (LGN95_03845) 778855..779121 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGN95_RS03850 (LGN95_03850) 779102..779512 + 411 WP_002916310.1 protein YgfX Toxin
LGN95_RS03855 (LGN95_03855) 779519..780040 - 522 WP_008806427.1 flavodoxin FldB -
LGN95_RS03860 (LGN95_03860) 780141..781037 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
LGN95_RS03865 (LGN95_03865) 781060..781773 + 714 WP_136047536.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGN95_RS03870 (LGN95_03870) 781779..783512 + 1734 WP_136047537.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T219310 WP_002916310.1 NZ_CP084766:779102-779512 [Klebsiella variicola subsp. variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219310 NZ_CP116249:c4218239-4217952 [Enterobacter roggenkampii]
ATGCCAATGGAGTATGAGTGGGATAACAATAAGGCGAAAAGTAACCTGCAAAAACATGGCATACGCTTTGAGGATGCGGT
TATGGTTTTCGACGATCCTTATCATTTGTCTGTTCAGGATCGCTATGAAAACGGGAAATTTCGCTGGCAAACCATCGGCC
TTGTGCAAGGCCTTCTTGTTATTTTGGTCGCACATACGGTACGTTTTGAAAGCGGAGGAGAAATCATCCGTATCATTAGC
GCACGAAAGGCGGACCGCAAAGAGAGGAGCCGTTATGAGCATCGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219310 WP_002916312.1 NZ_CP084766:778855-779121 [Klebsiella variicola subsp. variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219310 NZ_CP116249:c4217965-4217663 [Enterobacter roggenkampii]
ATGAGCATCGTTAAACATAAACGCGGTAGTGCGCCTGAGGTAAGCGCTCGTCGTGTGGCTGAGCTCAAAGCATTAGCTGA
AAAACCAGATGCGGAGATTGATTACAGCGATATTCCTGCCACGGACGATGAACAGTGGTCAGGGGCGGTGCGAGGGAAGT
TCTATCGACCACTCAAAACTCAGGCATCTGTACGCATTGACGCCGATGTGATGGAGTGGCTTAAACGGCCTGGGAAAGGT
TATCAGACGCGGCTCAATGCCATTTTGCGTGAAGCAATGCTGCGCGATCAAAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References