Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1299175..1299710 Replicon chromosome
Accession NC_008800
Organism Yersinia enterocolitica subsp. enterocolitica 8081

Toxin (Protein)


Gene name relE Uniprot ID A0A8B6KW45
Locus tag YE_RS05850 Protein ID WP_005172322.1
Coordinates 1299423..1299710 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8B6KUS5
Locus tag YE_RS05845 Protein ID WP_005172325.1
Coordinates 1299175..1299426 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YE_RS05820 (YE1154) 1294605..1295108 + 504 WP_005172332.1 ferredoxin-type protein NapF -
YE_RS05825 (YE1155) 1295098..1295364 + 267 WP_005165688.1 chaperone NapD -
YE_RS05830 (YE1156) 1295361..1297856 + 2496 WP_011815828.1 nitrate reductase catalytic subunit NapA -
YE_RS05835 (YE1157) 1297927..1298394 + 468 WP_005165692.1 nitrate reductase cytochrome c-type subunit -
YE_RS05840 (YE1158) 1298422..1299021 + 600 WP_011815830.1 cytochrome c-type protein NapC -
YE_RS05845 (YE1159) 1299175..1299426 + 252 WP_005172325.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
YE_RS05850 (YE1160) 1299423..1299710 + 288 WP_005172322.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
YE_RS05855 (YE1161) 1299739..1300314 + 576 WP_011815831.1 GDP-mannose pyrophosphatase NudK -
YE_RS05860 (YE1162) 1300535..1302814 + 2280 WP_005172316.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
YE_RS05865 (YE1163) 1303231..1304250 - 1020 WP_011815832.1 IS110-like element ISYen1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1303231..1304250 1019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11076.06 Da        Isoelectric Point: 10.6907

>T21931 WP_005172322.1 NC_008800:1299423-1299710 [Yersinia enterocolitica subsp. enterocolitica 8081]
MTYIVKFRDEALKEWHKLDKTIQQQFAKKLKKCSENPHIESARLRGIKNGYKIKLRASGFRLVYEVIDGILVVAVVAVGK
RERSEVYKLASDRLR

Download         Length: 288 bp

>T21931 NC_008800:1299423-1299710 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGACTTATATCGTTAAATTCAGAGACGAAGCGCTAAAGGAATGGCACAAACTGGATAAGACGATACAACAGCAGTTTGC
CAAGAAATTAAAAAAATGCAGTGAAAATCCCCATATTGAAAGTGCCAGACTGCGGGGGATCAAGAATGGTTACAAAATTA
AATTACGTGCCTCTGGTTTTCGCCTCGTGTATGAAGTTATTGATGGTATTTTGGTAGTTGCAGTGGTTGCGGTAGGGAAA
AGAGAACGTAGTGAGGTTTATAAACTGGCCAGTGATAGATTACGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9270.53 Da        Isoelectric Point: 4.3287

>AT21931 WP_005172325.1 NC_008800:1299175-1299426 [Yersinia enterocolitica subsp. enterocolitica 8081]
MPSVILTDTSASVSELKKNPMATVNAGAGFPVAILNRNQPVFYCVPAELYEQIMEALDDHELARLVNERRNQPLHDIDLD
SYL

Download         Length: 252 bp

>AT21931 NC_008800:1299175-1299426 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGCCAAGTGTTATTTTGACAGATACCAGCGCGAGCGTAAGTGAACTGAAGAAAAATCCCATGGCGACAGTGAATGCTGG
GGCAGGTTTCCCTGTTGCTATTCTGAACCGTAATCAACCTGTATTTTATTGTGTGCCCGCTGAACTCTATGAGCAAATAA
TGGAAGCGCTTGATGATCATGAATTAGCCAGGCTGGTGAATGAACGTCGTAATCAACCACTTCATGATATTGATTTGGAT
AGCTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B6KW45

Antitoxin

Source ID Structure
AlphaFold DB A0A8B6KUS5

References