Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 711869..712644 Replicon chromosome
Accession NZ_CP084766
Organism Klebsiella variicola subsp. variicola strain 01A065

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag LGN95_RS03505 Protein ID WP_064170005.1
Coordinates 712159..712644 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag LGN95_RS03500 Protein ID WP_046881921.1
Coordinates 711869..712162 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGN95_RS03480 (LGN95_03480) 707125..707727 - 603 WP_008806490.1 short chain dehydrogenase -
LGN95_RS03485 (LGN95_03485) 707825..708736 + 912 WP_008806489.1 LysR family transcriptional regulator -
LGN95_RS03490 (LGN95_03490) 708737..709885 - 1149 WP_008806488.1 PLP-dependent aspartate aminotransferase family protein -
LGN95_RS03495 (LGN95_03495) 709897..711273 - 1377 WP_016161835.1 cystathionine beta-synthase -
LGN95_RS03500 (LGN95_03500) 711869..712162 + 294 WP_046881921.1 DUF1778 domain-containing protein Antitoxin
LGN95_RS03505 (LGN95_03505) 712159..712644 + 486 WP_064170005.1 GNAT family N-acetyltransferase Toxin
LGN95_RS03510 (LGN95_03510) 713348..713941 + 594 WP_004188553.1 hypothetical protein -
LGN95_RS03515 (LGN95_03515) 714038..714254 + 217 Protein_688 transposase -
LGN95_RS03525 (LGN95_03525) 714769..715482 - 714 WP_008806478.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 714038..714190 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17618.64 Da        Isoelectric Point: 8.5178

>T219309 WP_064170005.1 NZ_CP084766:712159-712644 [Klebsiella variicola subsp. variicola]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDGKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLRDLVH
A

Download         Length: 486 bp

>T219309 NZ_CP116249:3870243-3870584 [Enterobacter roggenkampii]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGCGAAGCCCTGCCTAGCACCCGTGGCTGTCTGGCAAATGCTACTGAC
CCGCCTGCTGAAACAGCACTATGGTCTCACCCTCAACGACACACCGTTCAGTGAGGAACGTGTTATACAGGAACATATCG
ATGCCGGAATCACGCTGGCTGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AACTGGCAGGAACAATCCCCTTATCTCCGGGCTGTAGACATTCTGCGAGCACGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10868.52 Da        Isoelectric Point: 10.2633

>AT219309 WP_046881921.1 NZ_CP084766:711869-712162 [Klebsiella variicola subsp. variicola]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEPQK

Download         Length: 294 bp

>AT219309 NZ_CP116249:3869905-3870222 [Enterobacter roggenkampii]
ATGAGCAACATTACATGGGGGCTGCAGCGGGATATCACGCCACGCCTGGGAGCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGTAAATTCAGTGACGTCGAATGCCGGAAGCTGGATGAAACATGCCCGC
ACTTTATCCGCCATATGGAGTCGATGCTAACCACCGGTGAACTCAGTCCCCAACACGCCCACTGCGTCACCCTGTACCAC
AACGGTTTCACCTGCGAAGCCGATACTCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References