Detailed information of TA system TA219306

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5118338..5120019
• Replicon: chromosome
• Accession: NZ_CP084765
• Organism: Klebsiella variicola subsp. variicola strain F2R9T

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: LGN93_RS24790
• Protein ID: WP_040971114.1
• Coordinates: 5118338..5119255 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A223UHG0
• Locus tag: LGN93_RS24795
• Protein ID: WP_040971113.1
• Coordinates: 5119261..5120019 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGN93_RS24770 (LGN93_24770)	5113644..5115164	+	1521	WP_008807253.1	sugar ABC transporter ATP-binding protein	-
LGN93_RS24775 (LGN93_24775)	5115161..5116159	+	999	WP_004206363.1	ribose ABC transporter permease	-
LGN93_RS24780 (LGN93_24780)	5116190..5117131	+	942	WP_012543155.1	ABC transporter substrate-binding protein	-
LGN93_RS24785 (LGN93_24785)	5117206..5118213	+	1008	WP_022065799.1	carbohydrate kinase family protein	-
LGN93_RS24790 (LGN93_24790)	5118338..5119255	-	918	WP_040971114.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LGN93_RS24795 (LGN93_24795)	5119261..5120019	-	759	WP_040971113.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LGN93_RS24800 (LGN93_24800)	5120104..5120832	-	729	WP_008807258.1	response regulator transcription factor	-
LGN93_RS24805 (LGN93_24805)	5121105..5123252	+	2148	WP_077598880.1	formate dehydrogenase subunit alpha	-
LGN93_RS24810 (LGN93_24810)	5123958..5124644	+	687	WP_008807260.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34737.11 Da
• Isoelectric Point: 5.4707

>T219306 WP_040971114.1 NZ_CP084765:c5119255-5118338 [Klebsiella variicola subsp. variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIAANLQQQ
AGMNAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDVDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T219306 NZ_CP116249:1980349-1980452 [Enterobacter roggenkampii]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28683.10 Da
• Isoelectric Point: 10.1988

>AT219306 WP_040971113.1 NZ_CP084765:c5120019-5119261 [Klebsiella variicola subsp. variicola]
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVMLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT219306 NZ_CP116249:c1980459-1980314 [Enterobacter roggenkampii]
AACAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Structures

Antitoxin

• AlphaFold DB: A0A223UHG0