Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2740248..2741836 | Replicon | chromosome |
| Accession | NZ_CP084765 | ||
| Organism | Klebsiella variicola subsp. variicola strain F2R9T | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A1F2MCM0 |
| Locus tag | LGN93_RS13395 | Protein ID | WP_008804919.1 |
| Coordinates | 2740248..2741570 (-) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A1F2MCN9 |
| Locus tag | LGN93_RS13400 | Protein ID | WP_008804920.1 |
| Coordinates | 2741570..2741836 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGN93_RS13380 (LGN93_13380) | 2735313..2737814 | + | 2502 | WP_040968504.1 | fimbria/pilus outer membrane usher protein | - |
| LGN93_RS13385 (LGN93_13385) | 2737802..2738806 | + | 1005 | WP_008804917.1 | fimbrial protein | - |
| LGN93_RS13390 (LGN93_13390) | 2738939..2740231 | + | 1293 | WP_016161010.1 | glycoside hydrolase family 10 protein | - |
| LGN93_RS13395 (LGN93_13395) | 2740248..2741570 | - | 1323 | WP_008804919.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| LGN93_RS13400 (LGN93_13400) | 2741570..2741836 | - | 267 | WP_008804920.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| LGN93_RS13405 (LGN93_13405) | 2742102..2742428 | - | 327 | WP_008804921.1 | hydroxyisourate hydrolase | - |
| LGN93_RS13410 (LGN93_13410) | 2742425..2742925 | - | 501 | WP_008804922.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| LGN93_RS13415 (LGN93_13415) | 2742903..2744282 | - | 1380 | WP_032730340.1 | nucleobase:cation symporter-2 family protein | - |
| LGN93_RS13420 (LGN93_13420) | 2744628..2745782 | + | 1155 | WP_040968503.1 | FAD-dependent urate hydroxylase HpxO | - |
| LGN93_RS13425 (LGN93_13425) | 2745763..2746686 | - | 924 | WP_038422542.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 48911.26 Da Isoelectric Point: 7.9109
>T219303 WP_008804919.1 NZ_CP084765:c2741570-2740248 [Klebsiella variicola subsp. variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T219303 NZ_CP116249:c1018219-1017890 [Enterobacter roggenkampii]
ATGCAAATCATATCATCAGCCCCTACACGGGCGGCTCCGCTCAGCCTGTCACCCGTTGAAATCTGGCAGCGGCTGCTAAC
TCATCTGTTATCGCAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTTATGAAACCACCATACGGGAACATATTG
ATGCAGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAAATACGGGCTTGTCCGTATCGACCGGAAAGGATTT
TCATGGCAAGAACAGACCCCGTATATTTCCGTAGTAGATATTCTGATGGCAAGGCGCTCGACCGGCCTGCTAAAAACTAC
CGTGAAATAA
ATGCAAATCATATCATCAGCCCCTACACGGGCGGCTCCGCTCAGCCTGTCACCCGTTGAAATCTGGCAGCGGCTGCTAAC
TCATCTGTTATCGCAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTTATGAAACCACCATACGGGAACATATTG
ATGCAGGAGTATCGCTCAGCGATGCGGTGAACTTTCTGGTAGAAAAATACGGGCTTGTCCGTATCGACCGGAAAGGATTT
TCATGGCAAGAACAGACCCCGTATATTTCCGTAGTAGATATTCTGATGGCAAGGCGCTCGACCGGCCTGCTAAAAACTAC
CGTGAAATAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9936.30 Da Isoelectric Point: 8.5912
>AT219303 WP_008804920.1 NZ_CP084765:c2741836-2741570 [Klebsiella variicola subsp. variicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW
Download Length: 267 bp
>AT219303 NZ_CP116249:c1018623-1018258 [Enterobacter roggenkampii]
ATGAACAATCACTCAGAATCCGGCACCAGGCCGGAGAATTCCGCCATCCAGCAATGGGGACTGAAGCGCGCTATAACACC
GTGTTTTGGCGCACGACTGGTTCAGGAGGGCAACCGTCTGCACTATCTGGCTGACCGCGCAGGATTTAGCGGGGCGTTCA
CCGACGATGTTGCAATGCACCTCGACCAGGCATTTCCGCTCATGATGAAGCAACTTGAGCTGATGCTGACCAGTGGAGAG
CTCAACCCTAGCCACCCGCACTGCGTCACGCTTTACCATAACGGGCTCACCTGCGAAGCCGACACACTCGGCTCCTGTGG
CTATGTCTACATTGCTATCTATCCTGAGCAGACTGAGCCGCAGTAA
ATGAACAATCACTCAGAATCCGGCACCAGGCCGGAGAATTCCGCCATCCAGCAATGGGGACTGAAGCGCGCTATAACACC
GTGTTTTGGCGCACGACTGGTTCAGGAGGGCAACCGTCTGCACTATCTGGCTGACCGCGCAGGATTTAGCGGGGCGTTCA
CCGACGATGTTGCAATGCACCTCGACCAGGCATTTCCGCTCATGATGAAGCAACTTGAGCTGATGCTGACCAGTGGAGAG
CTCAACCCTAGCCACCCGCACTGCGTCACGCTTTACCATAACGGGCTCACCTGCGAAGCCGACACACTCGGCTCCTGTGG
CTATGTCTACATTGCTATCTATCCTGAGCAGACTGAGCCGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1F2MCM0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1F2MCN9 |