Detailed information of TA system TA021930

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 582668..583202
• Replicon: chromosome
• Accession: NC_008800
• Organism: Yersinia enterocolitica subsp. enterocolitica 8081

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A1JJ38
• Locus tag: YE_RS02615
• Protein ID: WP_011815479.1
• Coordinates: 582912..583202 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A1JJ37
• Locus tag: YE_RS02610
• Protein ID: WP_005175264.1
• Coordinates: 582668..582922 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YE_RS02585 (YE0502)	578026..579096	+	1071	WP_005175277.1	LPS export ABC transporter permease LptG	-
YE_RS02595 (YE0505)	579768..581027	+	1260	Protein_483	integrase arm-type DNA-binding domain-containing protein	-
YE_RS02600 (YE0506)	581162..581476	-	315	WP_005175269.1	BrnA antitoxin family protein	-
YE_RS02605	581463..581738	-	276	WP_042661591.1	BrnT family toxin	-
YE_RS02610 (YE0510)	582668..582922	+	255	WP_005175264.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
YE_RS02615 (YE0510A)	582912..583202	+	291	WP_011815479.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
YE_RS02620 (YE0511)	583381..583731	-	351	Protein_488	transcriptional regulator	-
YE_RS02625 (YE0512)	583736..584098	+	363	Protein_489	hypothetical protein	-
YE_RS02630 (YE0513)	584459..584869	+	411	WP_005159173.1	GNAT family N-acetyltransferase	-
YE_RS02635 (YE0514)	584895..585584	+	690	WP_005175259.1	PAS and helix-turn-helix domain-containing protein	-
YE_RS02640 (YE0515)	585621..586928	+	1308	WP_005175249.1	cytosine permease	-
YE_RS02645	586978..587562	+	585	Protein_493	HEAT repeat domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11464.39 Da
• Isoelectric Point: 9.9816

>T21930 WP_011815479.1 NC_008800:582912-583202 [Yersinia enterocolitica subsp. enterocolitica 8081]
MTFNIDFDERALKEWHKLDKAIREQFKKKLRKLQENPYIESARLHGDLAGCFKIKLRASGFRLIYQVIDEEIVIWIVAVG
KREDEKAYDIAKKRIQ

Nucleotide

• Length: 291 bp

>T21930 NC_008800:582912-583202 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGACCTTTAATATCGACTTTGACGAACGGGCATTAAAAGAATGGCACAAACTAGATAAAGCTATCCGAGAGCAATTTAA
AAAGAAACTAAGAAAATTACAGGAAAATCCCTATATTGAGTCAGCACGTTTGCACGGTGATCTGGCTGGCTGTTTCAAAA
TAAAATTACGCGCATCTGGCTTTCGGTTGATTTACCAAGTTATCGATGAGGAGATTGTGATTTGGATCGTTGCTGTTGGT
AAACGGGAAGATGAAAAAGCTTATGATATTGCCAAGAAGCGAATCCAATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9680.07 Da
• Isoelectric Point: 4.8283

>AT21930 WP_005175264.1 NC_008800:582668-582922 [Yersinia enterocolitica subsp. enterocolitica 8081]
MSTIQIRVDDELKKSAYQAFEKLNLSPSDALRLFLRYVAENEKLPFSEVSVMVSNQDEDADILAVVRERLKNPAKRIRVN
IDDL

Nucleotide

• Length: 255 bp

>AT21930 NC_008800:582668-582922 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGAGTACTATCCAAATTCGTGTGGATGATGAACTGAAGAAAAGTGCATATCAGGCGTTTGAAAAACTGAATCTTTCGCC
TTCTGATGCACTACGTCTGTTCCTACGTTATGTTGCAGAGAACGAAAAGCTGCCATTTTCAGAAGTATCCGTCATGGTCA
GTAATCAAGATGAGGATGCTGATATCTTGGCTGTTGTCCGTGAACGTTTGAAAAATCCTGCCAAGCGTATCAGGGTAAAT
ATTGATGACCTTTAA

Structures

Toxin

• AlphaFold DB: A1JJ38

Antitoxin

• AlphaFold DB: A1JJ37