Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1839868..1840458 Replicon chromosome
Accession NZ_CP084765
Organism Klebsiella variicola subsp. variicola strain F2R9T

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag LGN93_RS08915 Protein ID WP_039104087.1
Coordinates 1840126..1840458 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag LGN93_RS08910 Protein ID WP_039104089.1
Coordinates 1839868..1840125 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGN93_RS08890 (LGN93_08890) 1835478..1836053 + 576 WP_012541129.1 hypothetical protein -
LGN93_RS08895 (LGN93_08895) 1836232..1837068 + 837 WP_008804155.1 alpha/beta hydrolase -
LGN93_RS08900 (LGN93_08900) 1837275..1838246 + 972 WP_008804156.1 sensor domain-containing diguanylate cyclase -
LGN93_RS08905 (LGN93_08905) 1838243..1839340 - 1098 WP_040968706.1 AarF/UbiB family protein -
LGN93_RS08910 (LGN93_08910) 1839868..1840125 + 258 WP_039104089.1 antitoxin Antitoxin
LGN93_RS08915 (LGN93_08915) 1840126..1840458 + 333 WP_039104087.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LGN93_RS08930 (LGN93_08930) 1840781..1842217 + 1437 WP_016161429.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
LGN93_RS08940 (LGN93_08940) 1842590..1844044 - 1455 WP_008804170.1 AMP nucleosidase -
LGN93_RS08945 (LGN93_08945) 1844175..1844420 - 246 WP_008804171.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11895.77 Da        Isoelectric Point: 10.1839

>T219294 WP_039104087.1 NZ_CP084765:1840126-1840458 [Klebsiella variicola subsp. variicola]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDAIINEVLARLDAILS

Download         Length: 333 bp

>T219294 NZ_CP116243:110022-110420 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATGAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9432.97 Da        Isoelectric Point: 4.4915

>AT219294 WP_039104089.1 NZ_CP084765:1839868-1840125 [Klebsiella variicola subsp. variicola]
MYKTRLKKVGGSIMLAVPPAVLKALELSIDSEVGMTIDNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp

>AT219294 NZ_CP116243:109795-110022 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References