Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1647419..1648416 Replicon chromosome
Accession NZ_CP084765
Organism Klebsiella variicola subsp. variicola strain F2R9T

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LGN93_RS08105 Protein ID WP_229531768.1
Coordinates 1647862..1648416 (-) Length 185 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LGN93_RS08100 Protein ID WP_040968744.1
Coordinates 1647419..1647865 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGN93_RS08085 (LGN93_08085) 1643714..1644712 + 999 WP_008804028.1 galactose/glucose ABC transporter substrate-binding protein MglB -
LGN93_RS08090 (LGN93_08090) 1644831..1646351 + 1521 WP_008804029.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
LGN93_RS08095 (LGN93_08095) 1646367..1647377 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
LGN93_RS08100 (LGN93_08100) 1647419..1647865 - 447 WP_040968744.1 helix-turn-helix transcriptional regulator Antitoxin
LGN93_RS08105 (LGN93_08105) 1647862..1648416 - 555 WP_229531768.1 HipA domain-containing protein Toxin
LGN93_RS08110 (LGN93_08110) 1648445..1648966 - 522 WP_023340544.1 hypothetical protein -
LGN93_RS08115 (LGN93_08115) 1649081..1649812 - 732 WP_008804033.1 outer membrane permeability protein SanA -
LGN93_RS08120 (LGN93_08120) 1650105..1650989 - 885 WP_012541034.1 cytidine deaminase -
LGN93_RS08125 (LGN93_08125) 1651118..1651813 - 696 WP_008804035.1 CidB/LrgB family autolysis modulator -
LGN93_RS08130 (LGN93_08130) 1651803..1652207 - 405 WP_004201620.1 CidA/LrgA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(2-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20710.03 Da        Isoelectric Point: 5.7891

>T219293 WP_229531768.1 NZ_CP084765:c1648416-1647862 [Klebsiella variicola subsp. variicola]
MRLGMESVYSLLQKAPATILDHETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEIILAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWITPDTLLNALSETASQLVDLPSRLKVRGVP
VQILEMPSIGFKFIPDKLARWGLL

Download         Length: 555 bp

>T219293 NZ_CP116243:c97579-97430 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16422.09 Da        Isoelectric Point: 10.4705

>AT219293 WP_040968744.1 NZ_CP084765:c1647865-1647419 [Klebsiella variicola subsp. variicola]
MKTLNKKETEIQNTLARLRADNPPSLPATGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIYDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp

>AT219293 NZ_CP116243:97623-97684 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References