Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 825689..826346 Replicon chromosome
Accession NZ_CP084765
Organism Klebsiella variicola subsp. variicola strain F2R9T

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LGN93_RS04085 Protein ID WP_002916310.1
Coordinates 825936..826346 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGN93_RS04080 Protein ID WP_002916312.1
Coordinates 825689..825955 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGN93_RS04055 (LGN93_04055) 822131..822859 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
LGN93_RS04060 (LGN93_04060) 822910..823221 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
LGN93_RS04065 (LGN93_04065) 823385..824044 + 660 WP_008806429.1 hemolysin III family protein -
LGN93_RS04070 (LGN93_04070) 824075..824413 + 339 WP_136071171.1 hypothetical protein -
LGN93_RS04075 (LGN93_04075) 824460..825443 - 984 WP_008806428.1 tRNA-modifying protein YgfZ -
LGN93_RS04080 (LGN93_04080) 825689..825955 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGN93_RS04085 (LGN93_04085) 825936..826346 + 411 WP_002916310.1 protein YgfX Toxin
LGN93_RS04090 (LGN93_04090) 826353..826874 - 522 WP_008806427.1 flavodoxin FldB -
LGN93_RS04095 (LGN93_04095) 826975..827871 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
LGN93_RS04100 (LGN93_04100) 827894..828607 + 714 WP_008806425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGN93_RS04105 (LGN93_04105) 828613..830346 + 1734 WP_008806424.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T219292 WP_002916310.1 NZ_CP084765:825936-826346 [Klebsiella variicola subsp. variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219292 NZ_CP116243:c94047-93760 [Escherichia coli]
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAGGAATGGCTGAAACTGGATAAGACCATTCAACAACAGTTTGT
GAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCGTCAGCAAAACTAAGAGGGCTAAAGGATTGCTACAAAATTA
AACTACGTGCATCGGGATTTCGTCTGGTTTATCAGGTGATTGACGATATGTTAATTATTGCGGTTGTTGCGGTAGGAAAA
CGAGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219292 WP_002916312.1 NZ_CP084765:825689-825955 [Klebsiella variicola subsp. variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219292 NZ_CP116243:c94295-94044 [Escherichia coli]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTAGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References