Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 6094..6680 Replicon plasmid unnamed2
Accession NZ_CP084760
Organism UNVERIFIED_ORG: Shinella sp. XGS7

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LHJ69_RS24180 Protein ID WP_226882638.1
Coordinates 6094..6354 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LHJ69_RS24185 Protein ID WP_206366716.1
Coordinates 6351..6680 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHJ69_RS24145 (LHJ69_24135) 1219..1458 + 240 WP_249225879.1 DUF3768 domain-containing protein -
LHJ69_RS24155 (LHJ69_24145) 2122..2544 - 423 WP_226882633.1 hypothetical protein -
LHJ69_RS24160 (LHJ69_24150) 2952..3686 + 735 WP_226882634.1 ParA family protein -
LHJ69_RS24165 (LHJ69_24155) 3683..4018 + 336 WP_226882635.1 hypothetical protein -
LHJ69_RS24170 (LHJ69_24160) 4097..5317 + 1221 WP_226882636.1 replication initiator protein A -
LHJ69_RS24175 (LHJ69_24165) 5391..5558 + 168 WP_226882637.1 hypothetical protein -
LHJ69_RS24180 (LHJ69_24170) 6094..6354 + 261 WP_226882638.1 type II toxin-antitoxin system HicA family toxin Toxin
LHJ69_RS24185 (LHJ69_24175) 6351..6680 + 330 WP_206366716.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LHJ69_RS24190 (LHJ69_24180) 6683..6898 + 216 WP_226882639.1 hypothetical protein -
LHJ69_RS24195 (LHJ69_24185) 7159..7719 + 561 WP_226882640.1 hypothetical protein -
LHJ69_RS24200 (LHJ69_24190) 7991..8317 - 327 WP_226882641.1 hypothetical protein -
LHJ69_RS24205 (LHJ69_24195) 8526..9473 + 948 WP_226882642.1 MobQ family relaxase -
LHJ69_RS24210 (LHJ69_24200) 9518..9910 - 393 WP_024899725.1 hypothetical protein -
LHJ69_RS24215 (LHJ69_24205) 10118..10744 + 627 WP_024899726.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..18961 18961


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-75)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9574.03 Da        Isoelectric Point: 9.3476

>T219288 WP_226882638.1 NZ_CP084760:6094-6354 [Shinella sp. XGS7]
MELSRKHQATLEAVFAEPVRASIPWRDIEAMLAACGAEITEGQGSRVRIALNGVRAVFHRPHPQKETDKGAVKSVRRFLL
EAEIQP

Download         Length: 261 bp

>T219288 NZ_CP116242:c5719-5567 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12111.67 Da        Isoelectric Point: 4.6207

>AT219288 WP_206366716.1 NZ_CP084760:6351-6680 [Shinella sp. XGS7]
MTMMHYKGYEAVVEFDEEAEIFHGEVINLRDVITFQGASAAELKQAFAESVEDYLAFCAERGEEPEKPFSGQFVVRTEPG
LHKALTVAARRAGVSLNKWVTSTLERAVG

Download         Length: 330 bp

>AT219288 NZ_CP116242:5774-5831 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References