Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 6099..6685 Replicon plasmid unnamed4
Accession NZ_CP084756
Organism UNVERIFIED_ORG: Kinneretia sp. XES5

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LHK14_RS27875 Protein ID WP_226882638.1
Coordinates 6099..6359 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LHK14_RS27880 Protein ID WP_206366716.1
Coordinates 6356..6685 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHK14_RS27840 (LHK14_27840) 1224..1463 + 240 WP_249225879.1 DUF3768 domain-containing protein -
LHK14_RS27850 (LHK14_27850) 2127..2549 - 423 WP_226882633.1 hypothetical protein -
LHK14_RS27855 (LHK14_27855) 2957..3691 + 735 WP_226882634.1 ParA family protein -
LHK14_RS27860 (LHK14_27860) 3688..4023 + 336 WP_226882635.1 hypothetical protein -
LHK14_RS27865 (LHK14_27865) 4102..5322 + 1221 WP_226882636.1 replication initiator protein A -
LHK14_RS27870 (LHK14_27870) 5396..5563 + 168 WP_226882637.1 hypothetical protein -
LHK14_RS27875 (LHK14_27875) 6099..6359 + 261 WP_226882638.1 type II toxin-antitoxin system HicA family toxin Toxin
LHK14_RS27880 (LHK14_27880) 6356..6685 + 330 WP_206366716.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LHK14_RS27885 (LHK14_27885) 7164..7724 + 561 WP_226882640.1 hypothetical protein -
LHK14_RS27890 (LHK14_27890) 7996..8322 - 327 WP_226882641.1 hypothetical protein -
LHK14_RS27895 (LHK14_27895) 8531..9478 + 948 WP_226882642.1 MobQ family relaxase -
LHK14_RS27900 (LHK14_27900) 9523..9915 - 393 WP_024899725.1 hypothetical protein -
LHK14_RS27905 (LHK14_27905) 10123..10749 + 627 WP_024899726.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..18961 18961


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-75)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9574.03 Da        Isoelectric Point: 9.3476

>T219286 WP_226882638.1 NZ_CP084756:6099-6359 [Kinneretia sp. XES5]
MELSRKHQATLEAVFAEPVRASIPWRDIEAMLAACGAEITEGQGSRVRIALNGVRAVFHRPHPQKETDKGAVKSVRRFLL
EAEIQP

Download         Length: 261 bp

>T219286 NZ_CP116241:4167230-4167565 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12111.67 Da        Isoelectric Point: 4.6207

>AT219286 WP_206366716.1 NZ_CP084756:6356-6685 [Kinneretia sp. XES5]
MTMMHYKGYEAVVEFDEEAEIFHGEVINLRDVITFQGASAAELKQAFAESVEDYLAFCAERGEEPEKPFSGQFVVRTEPG
LHKALTVAARRAGVSLNKWVTSTLERAVG

Download         Length: 330 bp

>AT219286 NZ_CP116241:4166982-4167230 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGAGATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References