Detailed information of TA system TA219284

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 452130..452746
• Replicon: chromosome
• Accession: NZ_CP084752
• Organism: UNVERIFIED_ORG: Kinneretia sp. XES5

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LHK14_RS02470
• Protein ID: WP_226919801.1
• Coordinates: 452130..452492 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: LHK14_RS02475
• Protein ID: WP_226919802.1
• Coordinates: 452489..452746 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LHK14_RS02440 (LHK14_02440)	447506..448147	+	642	WP_226919795.1	HD family hydrolase	-
LHK14_RS02445 (LHK14_02445)	448150..448683	+	534	WP_226919796.1	tyrosine phosphatase family protein	-
LHK14_RS02450 (LHK14_02450)	448680..449648	+	969	WP_226919797.1	hypothetical protein	-
LHK14_RS02455 (LHK14_02455)	449773..450621	+	849	WP_226919798.1	mechanosensitive ion channel family protein	-
LHK14_RS02460 (LHK14_02460)	450625..451146	-	522	WP_226919799.1	superoxide dismutase family protein	-
LHK14_RS02465 (LHK14_02465)	451220..452125	-	906	WP_226919800.1	carboxylating nicotinate-nucleotide diphosphorylase	-
LHK14_RS02470 (LHK14_02470)	452130..452492	-	363	WP_226919801.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LHK14_RS02475 (LHK14_02475)	452489..452746	-	258	WP_226919802.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
LHK14_RS02480 (LHK14_02480)	452808..454406	-	1599	WP_226919803.1	L-aspartate oxidase	-
LHK14_RS02485 (LHK14_02485)	454580..455659	-	1080	WP_226919804.1	quinolinate synthase NadA	-
LHK14_RS02490 (LHK14_02490)	455829..457064	-	1236	WP_226919805.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-106)

Antitoxin

• Antitoxin ParD (6-63)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13385.25 Da
• Isoelectric Point: 8.6697

>T219284 WP_226919801.1 NZ_CP084752:c452492-452130 [Kinneretia sp. XES5]
MIVRLTRAAEQDLAEIARHTVATFGADQAMRYAALIEHALGLLADNPHRPASRERDELQPGVRSMHLSRAAARRHAASHV
LYYHLASGAGGERHVVILRVLHERMEPLKWLADANSPEKD

Nucleotide

• Length: 363 bp

>T219284 NZ_CP116241:c3769113-3768649 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9221.30 Da
• Isoelectric Point: 4.2958

>AT219284 WP_226919802.1 NZ_CP084752:c452746-452489 [Kinneretia sp. XES5]
MPTLNVSLTPEFADFIEDAVASGSYVSASEVVRDALRLMRQEQESEAAKLAILRKAVDTGLTQSQRGEFSDRSVSDIFAA
AVREA

Nucleotide

• Length: 258 bp

>AT219284 NZ_CP116241:c3769448-3769113 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA