Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 439920..440605 Replicon chromosome
Accession NZ_CP084752
Organism UNVERIFIED_ORG: Kinneretia sp. XES5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LHK14_RS02380 Protein ID WP_226919783.1
Coordinates 439920..440336 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LHK14_RS02385 Protein ID WP_226919784.1
Coordinates 440333..440605 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHK14_RS02355 (LHK14_02355) 435668..437284 - 1617 WP_226919778.1 citramalate synthase -
LHK14_RS02360 (LHK14_02360) 437384..438343 - 960 WP_226919779.1 prolyl aminopeptidase -
LHK14_RS02365 (LHK14_02365) 438340..438819 - 480 WP_226919780.1 GFA family protein -
LHK14_RS02370 (LHK14_02370) 438947..439444 - 498 WP_226919781.1 GFA family protein -
LHK14_RS02375 (LHK14_02375) 439441..439923 - 483 WP_226919782.1 GFA family protein -
LHK14_RS02380 (LHK14_02380) 439920..440336 - 417 WP_226919783.1 type II toxin-antitoxin system VapC family toxin Toxin
LHK14_RS02385 (LHK14_02385) 440333..440605 - 273 WP_226919784.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LHK14_RS02390 (LHK14_02390) 440669..442102 - 1434 WP_226919785.1 cysteine--tRNA ligase -
LHK14_RS02395 (LHK14_02395) 442215..442454 + 240 WP_226919786.1 hypothetical protein -
LHK14_RS02400 (LHK14_02400) 442560..442745 + 186 WP_226919787.1 hypothetical protein -
LHK14_RS02405 (LHK14_02405) 442747..443523 - 777 WP_226919788.1 SOS response-associated peptidase -
LHK14_RS02410 (LHK14_02410) 443584..444018 + 435 WP_226919789.1 NUDIX hydrolase -
LHK14_RS02415 (LHK14_02415) 444015..444500 + 486 WP_226919790.1 TIGR02301 family protein -
LHK14_RS02420 (LHK14_02420) 444605..444862 + 258 WP_226919791.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-126)

Antitoxin

SpoVT-AbrB domain

(20-55)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14989.09 Da        Isoelectric Point: 4.7381

>T219283 WP_226919783.1 NZ_CP084752:c440336-439920 [Kinneretia sp. XES5]
VTAFRYMLDTNVISDMVRNPDGLAARRVSSLDDDALCTSAIVASELRYGLRKSGAVALARRVEAVLGEMEILSYDAPVSF
AYAQARSTLEKKGQPIGATDLFIAAHALSLDLTLVTANVREFSRVEGLKVENWLEDAP

Download         Length: 417 bp

>T219283 NZ_CP116241:c3430207-3430100 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10379.84 Da        Isoelectric Point: 4.6265

>AT219283 WP_226919784.1 NZ_CP084752:c440605-440333 [Kinneretia sp. XES5]
MNARAKEMPEAVQEREVKLFRNGRNQAVRIPVEFELPGNEAVMRKEGDRLIIEPKHRKMGLAALLATFEPWEGDFPDLDE
RQPPPEDVDL

Download         Length: 273 bp

>AT219283 NZ_CP116241:3430255-3430321 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References