Detailed information of TA system TA021928

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 875921..876423
• Replicon: chromosome
• Accession: NC_008789
• Organism: Halorhodospira halophila SL1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A1WV57
• Locus tag: HHAL_RS04025
• Protein ID: WP_011813592.1
• Coordinates: 875921..876175 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A1WV58
• Locus tag: HHAL_RS04030
• Protein ID: WP_011813593.1
• Coordinates: 876172..876423 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHAL_RS03995	872433..873086	-	654	WP_049751433.1	DDE-type integrase/transposase/recombinase	-
HHAL_RS04000	873083..873466	-	384	WP_011813585.1	transposase	-
HHAL_RS13430	873571..873741	+	171	WP_011813586.1	hypothetical protein	-
HHAL_RS13255	873707..873907	+	201	WP_144446091.1	hypothetical protein	-
HHAL_RS04005	874134..874421	+	288	WP_011813587.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HHAL_RS04010	874405..874791	+	387	WP_011813588.1	type II toxin-antitoxin system VapC family toxin	-
HHAL_RS12945	874834..875016	+	183	Protein_804	hypothetical protein	-
HHAL_RS04020	875339..875569	+	231	WP_011813590.1	hypothetical protein	-
HHAL_RS12950	875566..876033	+	468	WP_011813591.1	type II toxin-antitoxin system VapC family toxin	-
HHAL_RS04025	875921..876175	-	255	WP_011813592.1	Txe/YoeB family addiction module toxin	Toxin
HHAL_RS04030	876172..876423	-	252	WP_011813593.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HHAL_RS04035	877016..877422	-	407	Protein_809	type II toxin-antitoxin system VapC family toxin	-
HHAL_RS04040	877425..877664	-	240	WP_011813595.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
HHAL_RS13265	878041..878916	+	876	WP_011813596.1	hypothetical protein	-
HHAL_RS12955	878917..879867	+	951	WP_011813597.1	glycosyltransferase family 2 protein	-
HHAL_RS13270	879860..881257	+	1398	WP_011813598.1	O-antigen ligase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	835221..882010	46789

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10191.67 Da
• Isoelectric Point: 9.5893

>T21928 WP_011813592.1 NC_008789:c876175-875921 [Halorhodospira halophila SL1]
MRLIFSENAWEDYLYWQKNDKATLRRINKLIRETQRAPFEGLGKPEPLKHGLAGYWSRRIDEEYRMVYKVGDDGLLIAQL
RYHY

Nucleotide

• Length: 255 bp

>T21928 NC_008789:c876175-875921 [Halorhodospira halophila SL1]
ATGAGGCTGATCTTCTCCGAGAACGCCTGGGAAGACTACCTCTATTGGCAAAAGAACGATAAGGCGACCCTGCGGCGGAT
CAACAAGCTGATCCGGGAGACCCAGCGCGCGCCCTTTGAGGGCCTCGGCAAGCCCGAGCCACTCAAGCACGGCCTTGCCG
GCTACTGGTCTCGCCGGATCGATGAGGAGTACCGGATGGTGTACAAAGTCGGGGACGACGGGCTCTTGATCGCGCAGCTC
CGCTATCACTATTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9354.63 Da
• Isoelectric Point: 4.8096

>AT21928 WP_011813593.1 NC_008789:c876423-876172 [Halorhodospira halophila SL1]
MDAISYTAARRQLASTMDKVCEDHAPIIITRNKAQSVVMISLEDYEALQETAYLLRSPKNARRLLESVADLERGGGQERD
LME

Nucleotide

• Length: 252 bp

>AT21928 NC_008789:c876423-876172 [Halorhodospira halophila SL1]
ATGGACGCGATCAGCTACACAGCAGCACGCCGCCAGCTCGCGAGTACCATGGACAAAGTCTGCGAGGACCACGCACCGAT
TATCATCACCCGGAACAAGGCGCAGTCCGTGGTCATGATCTCCCTTGAGGACTACGAGGCGCTGCAAGAGACTGCTTACC
TGCTCCGCTCCCCGAAGAATGCTCGGCGTCTGCTGGAGTCCGTCGCCGATTTGGAACGGGGTGGTGGCCAGGAGAGGGAC
CTTATGGAATGA

Structures

Toxin

• AlphaFold DB: A1WV57

Antitoxin

• AlphaFold DB: A1WV58