219276

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4890797..4892385 Replicon chromosome
Accession NZ_CP084741
Organism Pectobacterium carotovorum strain A077-S18-O15

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LHL03_RS21810 Protein ID WP_138256143.1
Coordinates 4891066..4892385 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LHL03_RS21805 Protein ID WP_103943261.1
Coordinates 4890797..4891066 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHL03_RS21780 (LHL03_21780) 4886242..4886796 + 555 WP_138256140.1 TetR/AcrR family transcriptional regulator -
LHL03_RS21785 (LHL03_21785) 4886846..4887256 - 411 WP_117590526.1 helix-turn-helix domain-containing protein -
LHL03_RS21790 (LHL03_21790) 4887399..4888250 + 852 WP_138256141.1 SDR family oxidoreductase -
LHL03_RS21795 (LHL03_21795) 4888378..4889589 - 1212 WP_138256142.1 acyltransferase -
LHL03_RS21800 (LHL03_21800) 4890159..4890605 + 447 Protein_4254 alpha/beta hydrolase -
LHL03_RS21805 (LHL03_21805) 4890797..4891066 + 270 WP_103943261.1 helix-turn-helix domain-containing protein Antitoxin
LHL03_RS21810 (LHL03_21810) 4891066..4892385 + 1320 WP_138256143.1 type II toxin-antitoxin system HipA family toxin Toxin
LHL03_RS21815 (LHL03_21815) 4892418..4893782 - 1365 WP_138256144.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
LHL03_RS21820 (LHL03_21820) 4893910..4895544 - 1635 WP_010281240.1 membrane protein insertase YidC -
LHL03_RS21825 (LHL03_21825) 4895547..4895804 - 258 WP_010281237.1 membrane protein insertion efficiency factor YidD -
LHL03_RS21830 (LHL03_21830) 4895768..4896127 - 360 WP_010302382.1 ribonuclease P protein component -
LHL03_RS21835 (LHL03_21835) 4896146..4896286 - 141 WP_005976668.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-66)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49449.63 Da        Isoelectric Point: 6.5030

>T219276 WP_138256143.1 NZ_CP084741:4891066-4892385 [Pectobacterium carotovorum]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLDKVGKDSVGALQLVPQGTPVHDIKKIEYKALSEQQFENILTGYLYDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDDHWCLPLNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIANAFGLPVPHCFMINAGKIKVLAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVDPERDRYRFMQAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSRGKKYAIEQIFPRHFFQTAKAVGFARESMENILVEFSNTV
ETVMTTVRSQLPVDFPTHISEAILAGLQARSRRLMSGWE

Download         Length: 1320 bp

>T219276 NZ_CP116241:c2531548-2531198 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10062.40 Da        Isoelectric Point: 9.7281

>AT219276 WP_103943261.1 NZ_CP084741:4890797-4891066 [Pectobacterium carotovorum]
MMKITNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDTTNNEAS
VASSWKEEW

Download         Length: 270 bp

>AT219276 NZ_CP116241:c2531793-2531542 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References