Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1845480..1846033 Replicon chromosome
Accession NZ_CP084741
Organism Pectobacterium carotovorum strain A077-S18-O15

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag LHL03_RS08135 Protein ID WP_138255504.1
Coordinates 1845719..1846033 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag LHL03_RS08130 Protein ID WP_010305008.1
Coordinates 1845480..1845716 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHL03_RS08105 (LHL03_08105) 1841109..1841600 - 492 WP_138255508.1 TIR domain-containing protein -
LHL03_RS08110 (LHL03_08110) 1841637..1842662 - 1026 WP_138255507.1 putative DNA base hypermodification protein -
LHL03_RS08115 (LHL03_08115) 1842655..1843209 - 555 WP_138255506.1 adenylate kinase -
LHL03_RS08120 (LHL03_08120) 1843206..1844252 - 1047 WP_223806323.1 thymidylate synthase -
LHL03_RS08125 (LHL03_08125) 1844890..1845337 + 448 Protein_1581 ArdC family protein -
LHL03_RS08130 (LHL03_08130) 1845480..1845716 + 237 WP_010305008.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LHL03_RS08135 (LHL03_08135) 1845719..1846033 + 315 WP_138255504.1 CcdB family protein Toxin
LHL03_RS08140 (LHL03_08140) 1846067..1846235 - 169 Protein_1584 molybdopterin-guanine dinucleotide biosynthesis protein MobC -
LHL03_RS08150 (LHL03_08150) 1846694..1847491 - 798 WP_138255484.1 DgsA anti-repressor MtfA -
LHL03_RS08155 (LHL03_08155) 1847722..1848108 - 387 WP_138255483.1 lysozyme inhibitor LprI family protein -
LHL03_RS08160 (LHL03_08160) 1848351..1848830 + 480 WP_190306468.1 hypothetical protein -
LHL03_RS08165 (LHL03_08165) 1848885..1849481 - 597 WP_010307991.1 YolA family protein -
LHL03_RS08170 (LHL03_08170) 1850068..1850235 + 168 WP_010280855.1 YqaE/Pmp3 family membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1813199..1850235 37036


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11557.49 Da        Isoelectric Point: 8.0151

>T219272 WP_138255504.1 NZ_CP084741:1845719-1846033 [Pectobacterium carotovorum]
MQFTVYGNTGKNVVYPLLLDVTSDIIGQLNRRIVIPLLPIEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVHALG
AVFCDASQYRSQVKAALDFLIDGF

Download         Length: 315 bp

>T219272 NZ_CP116241:1012542-1012649 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8934.00 Da        Isoelectric Point: 7.1672

>AT219272 WP_010305008.1 NZ_CP084741:1845480-1845716 [Pectobacterium carotovorum]
MTAKPRNTQSVTITVERALLVRAREAGINLSATLSTALDAELRRHEAKKWQEENREALAALNRFHDEQGCFSDEYRTF

Download         Length: 237 bp

>AT219272 NZ_CP116241:c1012495-1012429 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References