Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 1546226..1547025 Replicon chromosome
Accession NZ_CP084741
Organism Pectobacterium carotovorum strain A077-S18-O15

Toxin (Protein)


Gene name hepT Uniprot ID A0A7V8TG63
Locus tag LHL03_RS06815 Protein ID WP_010296752.1
Coordinates 1546226..1546645 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID A0A094SX92
Locus tag LHL03_RS06820 Protein ID WP_039473810.1
Coordinates 1546642..1547025 (-) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHL03_RS06795 (LHL03_06795) 1541348..1541989 + 642 WP_010296746.1 uridine kinase -
LHL03_RS06800 (LHL03_06800) 1542097..1542678 + 582 WP_005974037.1 dCTP deaminase -
LHL03_RS06805 (LHL03_06805) 1542742..1544577 + 1836 WP_226509839.1 outer membrane assembly protein AsmA -
LHL03_RS06810 (LHL03_06810) 1544830..1546182 + 1353 WP_014914716.1 anaerobic C4-dicarboxylate transporter DcuC -
LHL03_RS06815 (LHL03_06815) 1546226..1546645 - 420 WP_010296752.1 DUF86 domain-containing protein Toxin
LHL03_RS06820 (LHL03_06820) 1546642..1547025 - 384 WP_039473810.1 nucleotidyltransferase domain-containing protein Antitoxin
LHL03_RS06825 (LHL03_06825) 1547139..1548725 - 1587 WP_039544050.1 TerC family protein -
LHL03_RS06830 (LHL03_06830) 1549367..1550452 + 1086 WP_226509840.1 UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase -
LHL03_RS06835 (LHL03_06835) 1550576..1551712 + 1137 WP_226509841.1 polysaccharide export protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(13-130)

Antitoxin

Polymerase beta, nucleotidyltransferase

(4-93)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16052.37 Da        Isoelectric Point: 6.9682

>T219271 WP_010296752.1 NZ_CP084741:c1546645-1546226 [Pectobacterium carotovorum]
MTDILLNKSSTIQRCLRRIREEFDTEEGFRQNFTKQDSVILNIQRACEAAIDIANYLIRIKQLGIPQSSRDSFALLAANQ
IITIDLSDNLQKMVGLRNIAVHDYQALNLDIVIHVISHRLSDFEHFIKQIARYSDSQHL

Download         Length: 420 bp

>T219271 NZ_CP116241:c756649-756473 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 14372.57 Da        Isoelectric Point: 4.7463

>AT219271 WP_039473810.1 NZ_CP084741:c1547025-1546642 [Pectobacterium carotovorum]
MFDKIVLTLKKQMPDIKIIYLFGSQATGNARADSDIDIAIMATRALDPVERWELSNQLAKEVGHDVDLIDLLQASTVLKM
EIVRNGKLLYDAETAAGEFEMTTLSMYQHLQKERADIIRSFNQDLKA

Download         Length: 384 bp

>AT219271 NZ_CP116241:c756427-756011 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTGACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V8TG63

Antitoxin

Source ID Structure
AlphaFold DB A0A094SX92

References