Detailed information of TA system TA021927

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 834970..835565
• Replicon: chromosome
• Accession: NC_008789
• Organism: Halorhodospira halophila SL1

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: A1WV16
• Locus tag: HHAL_RS03860
• Protein ID: WP_011813551.1
• Coordinates: 835221..835565 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: A1WV15
• Locus tag: HHAL_RS03855
• Protein ID: WP_011813550.1
• Coordinates: 834970..835224 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHAL_RS03835	830613..831851	-	1239	WP_011813546.1	DUF3375 domain-containing protein	-
HHAL_RS13230	832397..832828	+	432	WP_187147882.1	nucleotidyltransferase domain-containing protein	-
HHAL_RS03845	832825..833298	+	474	WP_011813548.1	hypothetical protein	-
HHAL_RS03850	833369..834523	-	1155	WP_011813549.1	site-specific integrase	-
HHAL_RS13235	834751..834888	-	138	WP_187147883.1	hypothetical protein	-
HHAL_RS03855	834970..835224	+	255	WP_011813550.1	antitoxin	Antitoxin
HHAL_RS03860	835221..835565	+	345	WP_011813551.1	PIN domain-containing protein	Toxin
HHAL_RS13240	835570..835698	-	129	WP_144446085.1	transposase	-
HHAL_RS03865	835801..837141	+	1341	WP_041595047.1	IS200/IS605 family accessory protein TnpB-related protein	-
HHAL_RS03870	837504..837824	+	321	WP_011813554.1	hypothetical protein	-
HHAL_RS03875	837989..838324	+	336	WP_041595048.1	nucleotidyltransferase domain-containing protein	-
HHAL_RS13425	838332..838487	-	156	WP_187147884.1	hypothetical protein	-
HHAL_RS03885	838797..839168	+	372	WP_011813556.1	nucleotidyltransferase domain-containing protein	-
HHAL_RS03890	839366..839623	+	258	Protein_768	MarR family EPS-associated transcriptional regulator	-
HHAL_RS12510	839680..840351	+	672	WP_144446086.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-74)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12785.79 Da
• Isoelectric Point: 7.7749

>T21927 WP_011813551.1 NC_008789:835221-835565 [Halorhodospira halophila SL1]
VTYLLDTNILIYLIKNRPPAVAERVNALPREDLLCMSFVTFAEQLKGAERSTRKAQVLQSLERLKQEIIVVYPDSPVICH
HYAEQFTLLNKCPPHSATQFPSGNESSVKAGFLG

Nucleotide

• Length: 345 bp

>T21927 NC_008789:835221-835565 [Halorhodospira halophila SL1]
GTGACTTACCTCCTGGACACGAACATCTTGATCTACCTGATCAAGAACCGCCCTCCCGCCGTGGCTGAGCGGGTCAACGC
CCTGCCCAGGGAAGATCTGCTCTGCATGTCGTTCGTGACCTTCGCGGAACAGCTCAAGGGCGCAGAAAGAAGCACCCGGA
AAGCGCAGGTCCTGCAGAGCCTGGAAAGGCTGAAACAGGAAATCATCGTGGTTTATCCCGATAGCCCCGTCATATGCCAC
CACTACGCGGAACAGTTCACCCTCTTGAACAAGTGCCCGCCGCATTCCGCGACTCAATTCCCGTCAGGGAATGAGTCGTC
GGTCAAGGCGGGCTTTCTTGGCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9610.62 Da
• Isoelectric Point: 4.3316

>AT21927 WP_011813550.1 NC_008789:834970-835224 [Halorhodospira halophila SL1]
MSEHITRVFQNGNSQAVRIPAAYRLDSDRVLIERNERGDLVLHPLPERRGDSLLAALEGFDDEFIAALEEERDQPQPPQD
RESL

Nucleotide

• Length: 255 bp

>AT21927 NC_008789:834970-835224 [Halorhodospira halophila SL1]
ATGAGCGAACACATTACCCGCGTATTCCAGAACGGAAACAGCCAGGCGGTGCGTATCCCCGCCGCATACCGCCTGGATAG
CGACCGCGTTTTGATCGAGCGCAATGAACGCGGCGATCTGGTGTTGCATCCGTTGCCCGAGAGGCGCGGCGATTCACTGC
TGGCGGCCCTGGAGGGGTTTGACGACGAGTTCATTGCGGCCTTGGAAGAGGAGCGGGACCAGCCGCAACCACCCCAGGAC
CGGGAGTCGCTGTGA

Structures

Toxin

• AlphaFold DB: A1WV16

Antitoxin

• AlphaFold DB: A1WV15