Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1039014..1039540 Replicon chromosome
Accession NZ_CP084741
Organism Pectobacterium carotovorum strain A077-S18-O15

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag LHL03_RS04605 Protein ID WP_226509774.1
Coordinates 1039014..1039319 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag LHL03_RS04610 Protein ID WP_226509775.1
Coordinates 1039322..1039540 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHL03_RS04585 (LHL03_04585) 1034848..1035141 + 294 WP_019844370.1 DUF1778 domain-containing protein -
LHL03_RS04590 (LHL03_04590) 1035138..1035626 + 489 WP_226509771.1 GNAT family N-acetyltransferase -
LHL03_RS04595 (LHL03_04595) 1036129..1037802 + 1674 WP_226509772.1 AAA family ATPase -
LHL03_RS04600 (LHL03_04600) 1037848..1038684 + 837 WP_226509773.1 DNA adenine methylase -
LHL03_RS04605 (LHL03_04605) 1039014..1039319 - 306 WP_226509774.1 type II toxin-antitoxin system toxin CcdB Toxin
LHL03_RS04610 (LHL03_04610) 1039322..1039540 - 219 WP_226509775.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
LHL03_RS04615 (LHL03_04615) 1039599..1040342 - 744 WP_226509776.1 MobC family replication-relaxation protein -
LHL03_RS04620 (LHL03_04620) 1040485..1040646 + 162 WP_165572346.1 hypothetical protein -
LHL03_RS04625 (LHL03_04625) 1041247..1041588 - 342 WP_039534136.1 hypothetical protein -
LHL03_RS04630 (LHL03_04630) 1041774..1041968 + 195 WP_015854710.1 YlcI/YnfO family protein -
LHL03_RS04635 (LHL03_04635) 1042078..1043337 - 1260 WP_039534139.1 integrase arm-type DNA-binding domain-containing protein -
LHL03_RS21855 1043888..1044019 + 132 WP_268939584.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1034593..1043514 8921


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11789.66 Da        Isoelectric Point: 4.6983

>T219269 WP_226509774.1 NZ_CP084741:c1039319-1039014 [Pectobacterium carotovorum]
MQFIVYQYKRASHYKMFVDVQSDIVETPKRRMVIPLIEAHHLSEKVNKTLFPLIRIDGEDYRLMTTELSSVPVEVIGEEI
ADLGEYADEIKDAINLMFWGI

Download         Length: 306 bp

>T219269 NZ_CP116241:347801-347904 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8216.22 Da        Isoelectric Point: 7.2038

>AT219269 WP_226509775.1 NZ_CP084741:c1039540-1039322 [Pectobacterium carotovorum]
MKHRVSVTVDKDNYQILSAAGVNISGLVNDVIGKEARRIKAEEWKKENREGMEEVARFIAQHGSFADENRSW

Download         Length: 219 bp

>AT219269 NZ_CP116241:c347942-347671 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References