Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1034848..1035626 Replicon chromosome
Accession NZ_CP084741
Organism Pectobacterium carotovorum strain A077-S18-O15

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag LHL03_RS04590 Protein ID WP_226509771.1
Coordinates 1035138..1035626 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag LHL03_RS04585 Protein ID WP_019844370.1
Coordinates 1034848..1035141 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHL03_RS04580 (LHL03_04580) 1033565..1034362 + 798 WP_226509770.1 thioesterase domain-containing protein -
LHL03_RS04585 (LHL03_04585) 1034848..1035141 + 294 WP_019844370.1 DUF1778 domain-containing protein Antitoxin
LHL03_RS04590 (LHL03_04590) 1035138..1035626 + 489 WP_226509771.1 GNAT family N-acetyltransferase Toxin
LHL03_RS04595 (LHL03_04595) 1036129..1037802 + 1674 WP_226509772.1 AAA family ATPase -
LHL03_RS04600 (LHL03_04600) 1037848..1038684 + 837 WP_226509773.1 DNA adenine methylase -
LHL03_RS04605 (LHL03_04605) 1039014..1039319 - 306 WP_226509774.1 type II toxin-antitoxin system toxin CcdB -
LHL03_RS04610 (LHL03_04610) 1039322..1039540 - 219 WP_226509775.1 type II toxin-antitoxin system antitoxin CcdA -
LHL03_RS04615 (LHL03_04615) 1039599..1040342 - 744 WP_226509776.1 MobC family replication-relaxation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1034593..1043514 8921


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-144)

Antitoxin

Vibrio phage ICP1, Orf50

(5-95)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17538.37 Da        Isoelectric Point: 7.8046

>T219268 WP_226509771.1 NZ_CP084741:1035138-1035626 [Pectobacterium carotovorum]
VISAPEPLRAEHILSSFCCGMESMDNWLKQRAMKNQVTGASRTFVSCDDSKVLAYYSLASSAVATNAAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGQGVGRALVRDAGIRVIQVADTIGIRGMLVHALSDEARDFYLRVGFEPSPIDPMMLMVTLGDLAA
IH

Download         Length: 489 bp

>T219268 NZ_CP116241:187102-187356 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10884.50 Da        Isoelectric Point: 10.1968

>AT219268 WP_019844370.1 NZ_CP084741:1034848-1035141 [Pectobacterium carotovorum]
MPVTNSVSVKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIDQRIIMADPDAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp

>AT219268 NZ_CP116241:186854-187105 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References