Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 768484..769144 Replicon chromosome
Accession NZ_CP084741
Organism Pectobacterium carotovorum strain A077-S18-O15

Toxin (Protein)


Gene name cptA Uniprot ID A0A837DIN4
Locus tag LHL03_RS03500 Protein ID WP_039275532.1
Coordinates 768731..769144 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1D7Z1Z6
Locus tag LHL03_RS03495 Protein ID WP_005971623.1
Coordinates 768484..768750 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHL03_RS03475 (LHL03_03475) 764599..765603 - 1005 WP_138254842.1 LacI family DNA-binding transcriptional regulator -
LHL03_RS03480 (LHL03_03480) 765658..766266 - 609 WP_014914174.1 HD domain-containing protein -
LHL03_RS03485 (LHL03_03485) 766545..767192 + 648 WP_226509743.1 hemolysin III family protein -
LHL03_RS03490 (LHL03_03490) 767247..768248 - 1002 WP_138254843.1 tRNA-modifying protein YgfZ -
LHL03_RS03495 (LHL03_03495) 768484..768750 + 267 WP_005971623.1 FAD assembly factor SdhE Antitoxin
LHL03_RS03500 (LHL03_03500) 768731..769144 + 414 WP_039275532.1 protein YgfX Toxin
LHL03_RS03505 (LHL03_03505) 769213..770148 + 936 WP_138254844.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
LHL03_RS03510 (LHL03_03510) 770189..770511 - 323 Protein_676 hypothetical protein -
LHL03_RS03515 (LHL03_03515) 770540..771058 - 519 WP_044204035.1 flavodoxin FldB -
LHL03_RS03520 (LHL03_03520) 771398..771784 - 387 WP_010301824.1 thioesterase family protein -
LHL03_RS03525 (LHL03_03525) 771992..773320 - 1329 WP_010301826.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16311.26 Da        Isoelectric Point: 10.7911

>T219266 WP_039275532.1 NZ_CP084741:768731-769144 [Pectobacterium carotovorum]
VAQWRCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLSLQAVNGKDKQQLWLASDSMGDDEWRHLRQILLQQKHWAR

Download         Length: 414 bp

>T219266 NZ_CP116239:c5736244-5736062 [Pseudomonas sp. TUM22785]
ATGCGCAGTCGTGAGGTGATAGAGAAGATCAAGGAGGATGGGTGGTACGAGGTGGAGGTGAAAGGCAGTCACCATCAGTT
CAAGCACCCGAATAAACCGGGACGGGTCACGGTCCCACACCCCAAGAGTGATCTACCCATAGGGACGGTACGCAGCATCC
TGAAACAAGCCGGCCTTCTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10507.94 Da        Isoelectric Point: 5.1392

>AT219266 WP_005971623.1 NZ_CP084741:768484-768750 [Pectobacterium carotovorum]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDTDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT219266 NZ_CP116239:c5736026-5735619 [Pseudomonas sp. TUM22785]
ATGAAATTTCCCCTCGTTCTGCATAAGGACCCTGACTCTGACTACGGCGTAACCGTGCCGGACGTGCCGGGTTGTTTCTC
TGCGGGCGCTACCGTGGCGGAAGCCCTGGAGAACGTGAAGGAGGCGCTTGCCCTTCACTTCGAAGGCCTGGTGGCGGATG
GCGAGGCACTGCCTCAAGCGCAGCAGATTGACGTCCACATTGGTAATCCCGACTTTGCCGGCGGCGTGTGGGCGGTGGTT
GAGTTCGACGTGACGCCCTACCTAGGCAAGGCCGTACGCTTCAATGCCACCCTGCCGGAGAACCTTCTGCAGCGGATCGA
TGAGCGCGTGAGTAAGGACGCCCGCTACGCCTCACGGTCCGGCTTTCTCGCCACTGCCGCGTTGCGCGAGCTTTCGGATG
CCGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837DIN4

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z1Z6

References