Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 215998..216615 | Replicon | chromosome |
| Accession | NZ_CP084741 | ||
| Organism | Pectobacterium carotovorum strain A077-S18-O15 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | C6DHN3 |
| Locus tag | LHL03_RS00960 | Protein ID | WP_010281507.1 |
| Coordinates | 216436..216615 (-) | Length | 60 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A7T5QP09 |
| Locus tag | LHL03_RS00955 | Protein ID | WP_010299285.1 |
| Coordinates | 215998..216408 (-) | Length | 137 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LHL03_RS00940 (LHL03_00940) | 211862..212905 | - | 1044 | WP_010299291.1 | DNA-binding transcriptional regulator CytR | - |
| LHL03_RS00945 (LHL03_00945) | 213215..215413 | - | 2199 | WP_180775880.1 | primosomal protein N' | - |
| LHL03_RS00950 (LHL03_00950) | 215686..215901 | + | 216 | WP_010281510.1 | 50S ribosomal protein L31 | - |
| LHL03_RS00955 (LHL03_00955) | 215998..216408 | - | 411 | WP_010299285.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LHL03_RS00960 (LHL03_00960) | 216436..216615 | - | 180 | WP_010281507.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LHL03_RS00965 (LHL03_00965) | 216715..217725 | - | 1011 | WP_039508126.1 | iron ABC transporter permease | - |
| LHL03_RS00970 (LHL03_00970) | 217722..218684 | - | 963 | WP_226509971.1 | ABC transporter substrate-binding protein | - |
| LHL03_RS00975 (LHL03_00975) | 218694..219491 | - | 798 | WP_203470641.1 | ABC transporter ATP-binding protein | - |
| LHL03_RS00980 (LHL03_00980) | 219708..220025 | - | 318 | WP_005973355.1 | met regulon transcriptional regulator MetJ | - |
| LHL03_RS00985 (LHL03_00985) | 220213..221373 | + | 1161 | WP_226509713.1 | cystathionine gamma-synthase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6560.69 Da Isoelectric Point: 10.7838
>T219262 WP_010281507.1 NZ_CP084741:c216615-216436 [Pectobacterium carotovorum]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI
Download Length: 180 bp
>T219262 NZ_CP116239:2796459-2797037 [Pseudomonas sp. TUM22785]
ATGAACATCGACAGGATCAAGGGACGGCTCGACTTCCTCCGCGAGGCGGAGCGCCTCAAGGACGTGCTGCGCAGCGCCCA
CACCTCCAGCGGGCGCGCCGAAAGCACCGCCGAACACAGCTGGCGCCTGTGCCTGATGGCCATCACCTTCGCCGATGAGC
TGGCCGGGCTCGACCTGCTGCGGGTGCTGAAGATGTGCGTGGTCCACGACCTGGGCGAAGCCATCCACGGCGACATCCCC
GCCATCGAGCAGGGCGGCCACCCCGACAAGGGCGCCCAGGAACGCGAAGACCTGCTGACCCTGACCCGCACCCTCGACGC
CGCGCTGCGCGACGAGATTCTCGCGCTGTGGGACGACTACGAGAACGCCGCCTCCCCCGAGGCGCTGGCGGTCAAGGCGC
TGGACAAGCTGGAGACCCTGCTGCAGCACAACCAGGGCGCCAACCCGGCGGACTTCGACTACGCCTTCAACCTCGGCTAC
GGGCGCCGCTACACCAGCGACGAGCCCCTGTTCGCGGCCATTCGCGAGCAGCTGGACGCAGGCACGCGGCAGCGCATGGA
AGCCCAGGCGGGCGAGTAG
ATGAACATCGACAGGATCAAGGGACGGCTCGACTTCCTCCGCGAGGCGGAGCGCCTCAAGGACGTGCTGCGCAGCGCCCA
CACCTCCAGCGGGCGCGCCGAAAGCACCGCCGAACACAGCTGGCGCCTGTGCCTGATGGCCATCACCTTCGCCGATGAGC
TGGCCGGGCTCGACCTGCTGCGGGTGCTGAAGATGTGCGTGGTCCACGACCTGGGCGAAGCCATCCACGGCGACATCCCC
GCCATCGAGCAGGGCGGCCACCCCGACAAGGGCGCCCAGGAACGCGAAGACCTGCTGACCCTGACCCGCACCCTCGACGC
CGCGCTGCGCGACGAGATTCTCGCGCTGTGGGACGACTACGAGAACGCCGCCTCCCCCGAGGCGCTGGCGGTCAAGGCGC
TGGACAAGCTGGAGACCCTGCTGCAGCACAACCAGGGCGCCAACCCGGCGGACTTCGACTACGCCTTCAACCTCGGCTAC
GGGCGCCGCTACACCAGCGACGAGCCCCTGTTCGCGGCCATTCGCGAGCAGCTGGACGCAGGCACGCGGCAGCGCATGGA
AGCCCAGGCGGGCGAGTAG
Antitoxin
Download Length: 137 a.a. Molecular weight: 14549.41 Da Isoelectric Point: 4.3391
>AT219262 WP_010299285.1 NZ_CP084741:c216408-215998 [Pectobacterium carotovorum]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDIPTVSSVGQLAKNSEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDIPTVSSVGQLAKNSEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR
Download Length: 411 bp
>AT219262 NZ_CP116239:2795788-2796345 [Pseudomonas sp. TUM22785]
ATGAACGACAGCCTTCTGAAACCGGCCGTGCTCGGCGTCGCGCTGCGGCGTTGGCGCCTGCTGCATCGGGTCAAGCAGGC
CCATGCGGCGCAGCTGTTCGGCGTGGCGCAATCGACCATCTCGCGTTGGGAAAGCGGCGTGCAGGAGATGGAGCCCGCCG
AGCGGGCGCGGGTGGAGCAGATGCTGGCCGCCCGGCTGGAGGCCGCAGCCGACCAGGCCCTGGCGCGGCTGGTGAGCGAC
AGCCCGCGCGCCGTGCACCTGGTCTGCGACCTGAGCCATCGCCTGCTGGCCTGTTCCGCCGCCCGCGCTGCCGAATTCTC
CATACCCCTGGCCGAGCTGATGGGGCGCTCGCTGTGGCGCTACGCAACGCCGGAGATCGCGCGCAAGGAAGCGGCCCTGG
ATGCCCTGGGCTGGCGCGACCTGCTGATGCCGCCGGCGCTGGAGTTCGGCAGTGGCACCAATGACTCCGCCATCGTGCCC
ATCCGCCAGGGCCTGTGCCGCTGGACGCGCATGACCCTCTCCGACGGCACCGCTGCGCGCCTGGTGGAAACCCTCTGA
ATGAACGACAGCCTTCTGAAACCGGCCGTGCTCGGCGTCGCGCTGCGGCGTTGGCGCCTGCTGCATCGGGTCAAGCAGGC
CCATGCGGCGCAGCTGTTCGGCGTGGCGCAATCGACCATCTCGCGTTGGGAAAGCGGCGTGCAGGAGATGGAGCCCGCCG
AGCGGGCGCGGGTGGAGCAGATGCTGGCCGCCCGGCTGGAGGCCGCAGCCGACCAGGCCCTGGCGCGGCTGGTGAGCGAC
AGCCCGCGCGCCGTGCACCTGGTCTGCGACCTGAGCCATCGCCTGCTGGCCTGTTCCGCCGCCCGCGCTGCCGAATTCTC
CATACCCCTGGCCGAGCTGATGGGGCGCTCGCTGTGGCGCTACGCAACGCCGGAGATCGCGCGCAAGGAAGCGGCCCTGG
ATGCCCTGGGCTGGCGCGACCTGCTGATGCCGCCGGCGCTGGAGTTCGGCAGTGGCACCAATGACTCCGCCATCGTGCCC
ATCCGCCAGGGCCTGTGCCGCTGGACGCGCATGACCCTCTCCGACGGCACCGCTGCGCGCCTGGTGGAAACCCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7W2I1S0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7T5QP09 |