Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 167670..168304 Replicon chromosome
Accession NZ_CP084741
Organism Pectobacterium carotovorum strain A077-S18-O15

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LHL03_RS00755 Protein ID WP_138255712.1
Coordinates 167670..167945 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LHL03_RS00760 Protein ID WP_103943768.1
Coordinates 167942..168304 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHL03_RS00740 (LHL03_00740) 164689..166059 - 1371 WP_010281575.1 envelope stress sensor histidine kinase CpxA -
LHL03_RS00745 (LHL03_00745) 166056..166754 - 699 WP_010308725.1 envelope stress response regulator transcription factor CpxR -
LHL03_RS00750 (LHL03_00750) 166908..167432 + 525 WP_138255711.1 cell-envelope stress modulator CpxP -
LHL03_RS00755 (LHL03_00755) 167670..167945 + 276 WP_138255712.1 type II toxin-antitoxin system HicA family toxin Toxin
LHL03_RS00760 (LHL03_00760) 167942..168304 + 363 WP_103943768.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LHL03_RS00765 (LHL03_00765) 168565..172308 + 3744 WP_138255713.1 DUF4132 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-85)

Antitoxin

Uncharacterised protein family HicB

(61-113)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10024.61 Da        Isoelectric Point: 11.1875

>T219261 WP_138255712.1 NZ_CP084741:167670-167945 [Pectobacterium carotovorum]
MQGKIASLRKKQRETLNQIFKTPVLSGVKWSSIESLVTALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVSL
REWLESIGVKP

Download         Length: 276 bp

>T219261 NZ_CP116239:1682647-1683522 [Pseudomonas sp. TUM22785]
ATGGACATGGCGCAGCCCCCCATCCCCACGACCCGCTTGCAACAGTGCTTCCCGGAGCGGCTGGTGACCGTCGCCGAGGG
AGCCCGGGTGGCCATCCGCGAGTGCGGCCAGGGCCCGGTGGTGGTGCTCCTGCATGGCATCGGTTCCGGTGCGGCGTCCT
GGCTGCATTGCGCCCAGCGCCTGGCCGGGGACCACCGCGTGATCGCCTGGGATGCCCCCGGCTATGGCCGGTCCACGCCA
CTGCCCGAGGCCCGGCCACGGGCGCTGGATTACGCCACCCGCCTGGATGGGCTGCTGGCGGCCCTGGATATCCAGCGGTG
CCTGCTGGTGGGGCACTCCCTCGGTGCCTTGATGGCCACCGCCTATGCGGCCAGCAGCGGCGCCCGGCGTGTGGCCCGGC
TGGTGTTGTTCAGCCCGGCTCGTGGTTATGGCGCCGAGCCCCTGCGGGAGGCTGGAAGGCGAGTGCGGCAGCAGCGCCTG
GACAGCCTCGAGCGGCTCGGCATCGGCGGCATGGCCTGCGAGCGTTCTGGCCGCCTGCTGGGGCGCAACCCCAGCGAGGA
TGCCCAGGCCTGGGTGCGCTGGAACATGGCCCGGCTGAACCCGGAAGGCTACCGCCAGGCGGTGGAGCTGCTCTGCGGTG
ACGACCTGCTGGGCCAGGGCCTGCCGGCGATGCCTTGTGAGGTGCACTGCGGCGAAGAGGACGCCATCACCGTGCCCGAA
GCCTGCGGCGTCCTTGCTCGGGCACTGGGTGCATCGTTCTCGCTGATTCCCGGGGCCGGCCATGCCTGCCCCATCGAACA
ACCCGAGGTGGTCGCAGGACGCATTGGCCACGCGCAACGCCTCATCGTTGAAGGAGCCGCCTGTGGAAAAGCCTGA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13564.40 Da        Isoelectric Point: 4.7739

>AT219261 WP_103943768.1 NZ_CP084741:167942-168304 [Pectobacterium carotovorum]
MTKALNTPNTMVVSGQPAIISYVPEIGMFRGKFIGLSGYCDFVADSINGLRREGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERHISVNTFIVETLSEHLKQA

Download         Length: 363 bp

>AT219261 NZ_CP116239:1683509-1684342 [Pseudomonas sp. TUM22785]
GTGGAAAAGCCTGACGACCCGCACGACAGGTACATCGTGCCCGGCCTGGAGCGCGGCCTGCGGCTGCTCTGCGAGTTCAG
CCGGAAGAACCGTACCCTCACCGCCCCCGAGCTGGCTCGGCGCCTGAAGTTGCCGCGCTCGACCCTCTTCCGGTTGCTGG
CCACGCTGGAGGCCATGGGCTTCGTCTGCCGCAACGGCAACGAATACCGCCTGGGCATGGCCGTGCTGCGCCTCGGCTTC
GAGTACCTGGCCTCCCTGGAACTCACTGAGCTGGGGCAGCCGCTGCTGAACCGGCTCTGCGACGAAGTCCGCTACCCCTG
CAACCTGGTGGTCCGCGATGGCCGCTCCATCGTCTACGTGGCCAAGGTCTCGCCGTCCACCTTGCTCACCAGCACCGTCA
ACGTCGGCACCCGCCTGCCGGCCCACGCCACGGTGCTCGGCCGCATCCTGCTGCAGGACCTGCCCTTCACCGAGTTGCGC
GAGTTGTACCCGGAAGAGCGGCTGGAGCGTTTCTCGCCTAACACCCCGGCAACCGTGCTGGAGCTGTTCGACCTGGTGCA
GGCCGACCGCCTGCGTGGCTTCGTCCAGGGCGAGGGCTTCTTCGAGGCGACCATCTCTACCGTGGCTGCACCAGTGCGTG
ACCACAGCGGCCGGGTGGTGGCCGCCGTCGGCGCGACCATCCCCTCGGGGCGCATCGAGCCGGACCTTCTCGATGGCCTG
GTGAGCAGCGTGCGCCATCACGCAGACGAACTCTCCCGCCTGCTCGACTACACCCCGGACGGCCGCGACAAGGTGGCTTC
CCACCATTGGAGCAAGCAGCATGAACCGGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References