Detailed information of TA system TA021926

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Txe-RelB
• Location: 474613..475133
• Replicon: chromosome
• Accession: NC_008789
• Organism: Halorhodospira halophila SL1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A1WU37
• Locus tag: HHAL_RS02085
• Protein ID: WP_011813222.1
• Coordinates: 474873..475133 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A1WU36
• Locus tag: HHAL_RS02080
• Protein ID: WP_011813221.1
• Coordinates: 474613..474876 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHAL_RS02060	470787..471566	-	780	WP_011813219.1	alpha/beta hydrolase	-
HHAL_RS02065	471700..472314	-	615	WP_011813220.1	heme-binding protein	-
HHAL_RS02070	472939..473595	+	657	WP_081432139.1	class I SAM-dependent methyltransferase	-
HHAL_RS02075	473567..474088	+	522	WP_187147875.1	hypothetical protein	-
HHAL_RS02080	474613..474876	+	264	WP_011813221.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HHAL_RS02085	474873..475133	+	261	WP_011813222.1	Txe/YoeB family addiction module toxin	Toxin
HHAL_RS02090	475347..476324	-	978	WP_011813223.1	hypothetical protein	-
HHAL_RS13405	476514..476666	-	153	WP_187147876.1	hypothetical protein	-
HHAL_RS02095	476768..477256	+	489	WP_041595301.1	GNAT family N-acetyltransferase	-
HHAL_RS02100	477881..479546	-	1666	Protein_419	IS1634 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	pilT	335985..492870	156885

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10265.76 Da
• Isoelectric Point: 8.5417

>T21926 WP_011813222.1 NC_008789:474873-475133 [Halorhodospira halophila SL1]
VRQVLLDPAALEDLQWWLRHDHRTARKILDLIEEAARNPFEGRGKPEAPKFELSGCWSRRINLEHRLVYEVSETSIRVLA
CRFHYR

Nucleotide

• Length: 261 bp

>T21926 NC_008789:474873-475133 [Halorhodospira halophila SL1]
GTGAGGCAGGTCCTTCTGGACCCAGCTGCCCTGGAAGACCTCCAGTGGTGGCTCCGGCATGATCACCGCACCGCCCGCAA
GATTCTGGACTTGATCGAGGAAGCGGCTCGTAACCCTTTCGAGGGACGGGGCAAGCCCGAAGCCCCCAAGTTCGAGCTTT
CGGGCTGCTGGTCCCGGCGGATCAACCTCGAGCACCGGCTGGTCTATGAGGTGAGCGAGACGTCCATCCGCGTGCTCGCC
TGCCGCTTTCATTACCGGTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9781.88 Da
• Isoelectric Point: 4.9108

>AT21926 WP_011813221.1 NC_008789:474613-474876 [Halorhodospira halophila SL1]
METISYTDARNHLKELIDRVGTDHTPVRIERRGGSAAVIMAEEDYTGLQETLYLLGNPANAERLRQARARGEEDAVSLED
AKERLAR

Nucleotide

• Length: 264 bp

>AT21926 NC_008789:474613-474876 [Halorhodospira halophila SL1]
ATGGAAACCATCAGCTATACGGATGCCCGGAACCACCTGAAGGAGCTCATCGACCGGGTCGGGACAGACCACACCCCCGT
GCGGATCGAGCGCCGCGGGGGTAGCGCAGCCGTCATCATGGCCGAAGAGGACTACACCGGGCTGCAGGAGACCCTGTACC
TGCTAGGCAACCCCGCCAACGCCGAGCGTCTGCGCCAGGCCCGGGCCCGCGGGGAAGAGGATGCGGTGTCGCTGGAGGAC
GCCAAGGAGAGGCTCGCGCGGTGA

Structures

Toxin

• AlphaFold DB: A1WU37

Antitoxin

• AlphaFold DB: A1WU36