Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2102834..2104422 Replicon chromosome
Accession NZ_CP084740
Organism Dickeya zeae strain A586-S18-A17

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LHK94_RS09450 Protein ID WP_226511521.1
Coordinates 2102834..2104153 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LHK94_RS09455 Protein ID WP_038915205.1
Coordinates 2104153..2104422 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHK94_RS09425 (LHK94_09430) 2098948..2099088 + 141 WP_000831330.1 50S ribosomal protein L34 -
LHK94_RS09430 (LHK94_09435) 2099107..2099466 + 360 WP_012886808.1 ribonuclease P protein component -
LHK94_RS09435 (LHK94_09440) 2099430..2099687 + 258 WP_012886807.1 membrane protein insertion efficiency factor YidD -
LHK94_RS09440 (LHK94_09445) 2099690..2101321 + 1632 WP_226511520.1 membrane protein insertase YidC -
LHK94_RS09445 (LHK94_09450) 2101437..2102801 + 1365 WP_210182046.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
LHK94_RS09450 (LHK94_09455) 2102834..2104153 - 1320 WP_226511521.1 type II toxin-antitoxin system HipA family toxin Toxin
LHK94_RS09455 (LHK94_09460) 2104153..2104422 - 270 WP_038915205.1 helix-turn-helix domain-containing protein Antitoxin
LHK94_RS09460 (LHK94_09465) 2104599..2105576 - 978 WP_226511522.1 helix-turn-helix domain-containing protein -
LHK94_RS09465 (LHK94_09470) 2105620..2106393 - 774 WP_012886800.1 MBL fold metallo-hydrolase -
LHK94_RS09470 (LHK94_09475) 2106714..2107802 + 1089 WP_226511523.1 4-hydroxyphenylpyruvate dioxygenase -
LHK94_RS09475 (LHK94_09480) 2107943..2108329 - 387 WP_226511524.1 helix-turn-helix domain-containing protein -
LHK94_RS09480 (LHK94_09485) 2108472..2109083 + 612 WP_210182051.1 NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49361.64 Da        Isoelectric Point: 7.0977

>T219252 WP_226511521.1 NZ_CP084740:c2104153-2102834 [Dickeya zeae]
MAALDVYMNGYRVGILTKTGSGAHHFSYDVNWLGLSGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLAKVGRDSVGALQLIPASTPTNNIKQIEYKTLSEQQLENILSGYLVDAPLGMIDTEDDFRISIAGAQEKTA
LLYRDNHWCLPFNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAREFGLPVPHCFMLKAGKIKALAVERFDRK
YASDGSWVMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSYLLGAVDPQRDRYSFMKVQVLFWLLAATDGHAKNFSLFI
EPEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLASSKGKKYAIEQIFPRHFFQTAQAVGFARESMESILTEFAQSM
DTIVMKIRNQLPASFPASIRDAILEGMQARAGRLMTGWE

Download         Length: 1320 bp

>T219252 NZ_CP116234:20978-21742 [Helicobacter pylori]
ATGGAAACTAAAGAAGAAGGTAAAGATAAAAAGCTAGAAAAAATTATTGTATTGCTGTGCGAAGAGGGGGATTTGTCTAG
CCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATAAAGGAGAATACAAGCATAAATATTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACACTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAACCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATTAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATAAAGTTAGAAGATGAACTAAATAAAAACTATAAAAAAT
TAAGTGAAGAATTGAATAAGCAACAAACACAATACATAACAATTCTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGTGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAGAAGAGAAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACTTATTTTTTGGTTTAATCTAATAGTTATAATTCTATTTGTGTTTGGTTTTTTT
GGAGAATTGCATATAATACAAAGATTAGTTTCTAAATATCTTTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10048.39 Da        Isoelectric Point: 8.5848

>AT219252 WP_038915205.1 NZ_CP084740:c2104422-2104153 [Dickeya zeae]
MKVTNSKQLSSYLKDVRIMQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNMDAANNEASV
AESSWKEEW

Download         Length: 270 bp

>AT219252 NZ_CP116234:20551-20988 [Helicobacter pylori]
ATGGTCAATACTTTGGAATTAGCAAAATATATTCTTAAGCATTCAAACAAAGGATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATTAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTGTTGCAAGAGAAGTGTATTATGAATATCGCAATTACGGTGCCAATTCTATTGACAAACCCAAAGAAGAAACACTC
TCACAAAATCTTAGAGAAGATGAACTTGAAACCATTAATTGCTCCATAAAAAAATGCAACGAGAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGCGCTTGGCATAAAAGCTTCAGAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCAAAACAAGCAAATGGAAACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References