Detailed information of TA system TA219249

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1373825..1374503
• Replicon: chromosome
• Accession: NZ_CP084740
• Organism: Dickeya zeae strain A586-S18-A17

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: D2BSA8
• Locus tag: LHK94_RS06080
• Protein ID: WP_012883372.1
• Coordinates: 1373825..1374256 (-)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: LHK94_RS06085
• Protein ID: WP_038906203.1
• Coordinates: 1374237..1374503 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LHK94_RS06060 (LHK94_06065)	1369744..1370460	-	717	WP_012883376.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LHK94_RS06065 (LHK94_06070)	1370548..1371447	-	900	WP_012883375.1	site-specific tyrosine recombinase XerD	-
LHK94_RS06070 (LHK94_06075)	1371711..1373036	+	1326	WP_226511273.1	MFS transporter	-
LHK94_RS06075 (LHK94_06080)	1373202..1373720	+	519	WP_226511274.1	flavodoxin FldB	-
LHK94_RS06080 (LHK94_06085)	1373825..1374256	-	432	WP_012883372.1	protein YgfX	Toxin
LHK94_RS06085 (LHK94_06090)	1374237..1374503	-	267	WP_038906203.1	FAD assembly factor SdhE	Antitoxin
LHK94_RS06090 (LHK94_06095)	1374812..1375792	+	981	WP_226511275.1	tRNA-modifying protein YgfZ	-
LHK94_RS06095 (LHK94_06100)	1375869..1376519	-	651	WP_038913159.1	hemolysin III family protein	-
LHK94_RS06100 (LHK94_06105)	1376732..1377340	+	609	WP_012883368.1	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16887.54 Da
• Isoelectric Point: 11.5023

>T219249 WP_012883372.1 NZ_CP084740:c1374256-1373825 [Dickeya zeae]
VAQWQCDLRVSWRMQLFSLLTHGFLMLMILLAPWPDGYAPLWLGLVTLVVFDFVRSQRSIKSRQGEISLRGDNQLHWQQR
DWQIVRRPWFMRNGVLLSLRAVDGKGQQRLWLASDSMGSEEWRLLRQQLQQPALHGTESSRHH

Nucleotide

• Length: 432 bp

>T219249 NZ_CP116231:c1820825-1820562 [Fusobacterium nucleatum]
ATGTATAAGGTATATTTTGACAAAAAAGTAGAAAAAGATTTTAAAAAATTAGATAAGAAAGTTTTAAAATTAATTTTAGA
TTGGATTGAAAATAATTTAGAAAATATAGAAGAACCAAGAAGTAAAGGAAAAGCATTAGTAGGAAATTTAAAGGATTATT
GGAGATATAGAATAGGTGATTATAGATTAATTACTAAAATTGATGATGGAAAACTATTAATCATTACATTAGAACTTAAA
CATAGGAAAGAAGTTTATGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10446.96 Da
• Isoelectric Point: 5.5981

>AT219249 WP_038906203.1 NZ_CP084740:c1374503-1374237 [Dickeya zeae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQQFIRLLQCDDPDLFNWLMNHGEPVDPGLKRMVSLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT219249 NZ_CP116231:c1821050-1820826 [Fusobacterium nucleatum]
ATGTCAAACATTACATTAAGATTAACAGATGAAGAAAGAGAAATACTGAACAATGTAGCTCATTTATATGGTGACAAATT
ATCAACAGCAATAAAAACAATATTATTTGAAAAAATAGAAGAAGACTATAATTTAAAAATAGTTAAAGATTTTGAAAAAA
GAGAAAAAGAAAATAAGGTGGAATTAGTTAGTTTATCTGATTTTAGAAAAAAGTTAGGTGTCTGA

Structures

Toxin

• AlphaFold DB: A0A2K9QB06